| Essentials of Th17 cell commitment and plasticity. | |
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MedLine Citation:
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PMID: 23325835 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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CD4(+) T helper (Th) cells exist in a variety of epigenetic states that determine their function, phenotype and capacity for persistence. These polarization states include Th1, Th2, Th17 and Foxp3(+) T regulatory cells (Treg), as well as the more recently described T follicular helper (Tfh), Th9 and Th22 cells. Th17 cells express the master transcriptional regulator RORγt and produce canonical IL-17A and IL-17F cytokines. Th17 cells display a great degree of context-dependent plasticity, as they are capable of acquiring functional characteristics of Th1 cells. This late plasticity may contribute to the protection against microbes, plays a role in development of autoimmunity and is necessary for anti-tumor activity of Th17 cells in adoptive cell transfer therapy models. Moreover, plasticity of this subset is associated with higher in vivo survival and self-renewal capacity and less senescence than Th1 polarized cells, which have less plasticity and more phenotypic stability. New findings indicate that subset polarization of CD4(+) T cells not only induces characteristic patterns of surface markers and cytokine production, but also has a maturational aspect that affects a cell's ability to survive, respond to secondary stimulation and form long-term immune memory. |
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Authors:
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Pawel Muranski; Nicholas P Restifo |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2013-1-16 |
Journal Detail:
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Title: Blood Volume: - ISSN: 1528-0020 ISO Abbreviation: Blood Publication Date: 2013 Jan |
Date Detail:
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Created Date: 2013-1-17 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7603509 Medline TA: Blood Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Hematology Branch, National Heart, Lung and Blood Institute, NIH, Bethesda, MD, United States; |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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