Document Detail

Essential thrombocythemia/polycythemia vera and pregnancy: the need for an observational study in Europe.
MedLine Citation:
PMID:  16810618     Owner:  NLM     Status:  MEDLINE    
The management of pregnant patients with essential thrombocythemia (ET) and polycythemia vera (PV) may be problematic. In the literature there are approximately 300 cases of pregnancies reported in ET and less than 50 pregnancies reported in PV. To reduce the effect of reporting bias, we selected articles with either > 10 pregnancies or at least six patients, and here report on the outcome of 195 pregnancies in ET and 36 pregnancies in PV patients. The live birth rate was approximately 60% in ET and 58% in PV. Spontaneous abortion during the first trimester was the most frequent fetal complication, occurring in 31% of ET pregnancies and in 22% of PV pregnancies, respectively. Major maternal complications were more frequent in PV compared with ET (44.4 versus 7.7%). Treatment with low-dose aspirin during pregnancy in ET seemed to reduce complications and also seemed beneficial during pregnancy in PV. In high-risk pregnancies, the additional use of low molecular weight heparin and/or interferon alpha should be considered. This article also describes a registry for an observational study concerning pregnancy in chronic Philadelphia chromosome-negative myeloproliferative disorders within the European LeukemiaNet. A potential management algorithm for pregnancies in ET or PV is also provided.
Martin Griesshammer; Sabine Struve; Claire M Harrison
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Seminars in thrombosis and hemostasis     Volume:  32     ISSN:  0094-6176     ISO Abbreviation:  Semin. Thromb. Hemost.     Publication Date:  2006 Jun 
Date Detail:
Created Date:  2006-06-30     Completed Date:  2006-08-25     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0431155     Medline TA:  Semin Thromb Hemost     Country:  United States    
Other Details:
Languages:  eng     Pagination:  422-9     Citation Subset:  IM    
Department of Medicine III, Medizinische Universitätsklinik, Ulm, Germany.
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MeSH Terms
Abortion, Spontaneous / epidemiology,  etiology
Polycythemia Vera* / drug therapy,  epidemiology
Pregnancy Complications, Hematologic* / drug therapy,  epidemiology
Pregnancy Outcome / epidemiology
Thrombocythemia, Essential* / drug therapy,  epidemiology

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