| [Essential tremor and Parkinson's disease: are they associated?]. | |
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MedLine Citation:
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PMID: 23055430 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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INTRODUCTION: There is now growing evidence that essential tremor and Parkinson's disease are related. AIM: To present the main findings from epidemiologic, genetic, clinical, imaging and pathologic studies, contrasting evidences for and against an association between essential tremor and Parkinson's disease. DEVELOPMENT: We include a complete update of the latest findings regarding the overlap between these two disorders. There is current evidence that a history of essential tremor may herald the onset of Parkinson's disease in a subset of patients. Furthermore, the fact that the risk of essential tremor is significantly increased in relatives of patients with Parkinson's disease suggests the possibility that both conditions are genetically related, probably sharing common hereditary predisposition. Dopaminergic deficit among essential tremor patients in functional imaging studies and recent pathological studies describing Lewy bodies in some essential tremor patients, support further evidence for an overlap between both conditions, at least in a subset of patients. CONCLUSION: The convergence of all the reviewed data suggests the possible existence of a mixed essential tremor-Parkinson's disease phenotype in some patients. However, further studies are needed to better understand this phenotype. |
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Authors:
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Andrés Labiano-Fontcuberta; Julián Benito-León |
Publication Detail:
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Type: English Abstract; Journal Article; Review |
Journal Detail:
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Title: Revista de neurologia Volume: 55 ISSN: 1576-6578 ISO Abbreviation: Rev Neurol Publication Date: 2012 Oct |
Date Detail:
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Created Date: 2012-10-11 Completed Date: 2013-04-05 Revised Date: 2013-04-19 |
Medline Journal Info:
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Nlm Unique ID: 7706841 Medline TA: Rev Neurol Country: Spain |
Other Details:
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Languages: spa Pagination: 479-89 Citation Subset: IM |
Affiliation:
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Servicio de Neurología, Hospital Universitario 12 de Octubre, Madrid, España. |
Vernacular Title:
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Temblor esencial y enfermedad de Parkinson: ¿existe una asociación? |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Age Factors Aged Depression / epidemiology, etiology Disease Progression Essential Tremor / complications*, epidemiology, genetics, pathology, physiopathology Genetic Predisposition to Disease Humans Incidence Lewy Bodies / ultrastructure Locus Coeruleus / pathology Membrane Proteins / genetics Middle Aged Nerve Tissue Proteins / genetics Neuroimaging Parkinson Disease / complications*, epidemiology, genetics, pathology, physiopathology, psychology Parkinsonian Disorders / epidemiology Prevalence Risk Tremor / classification, epidemiology |
| Chemical | |
Reg. No./Substance:
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0/LINGO1 protein, human; 0/Membrane Proteins; 0/Nerve Tissue Proteins |
| Comments/Corrections | |
Comment In:
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Rev Neurol. 2013 Mar 16;56(6):351-2
[PMID:
23483474
]
Rev Neurol. 2013 Mar 16;56(6):351 [PMID: 23483473 ] Rev Neurol. 2013 Mar 16;56(6):350-1 [PMID: 23483472 ] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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