Document Detail

[Essential tremor and Parkinson's disease: are they associated?].
MedLine Citation:
PMID:  23055430     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION: There is now growing evidence that essential tremor and Parkinson's disease are related.
AIM: To present the main findings from epidemiologic, genetic, clinical, imaging and pathologic studies, contrasting evidences for and against an association between essential tremor and Parkinson's disease.
DEVELOPMENT: We include a complete update of the latest findings regarding the overlap between these two disorders. There is current evidence that a history of essential tremor may herald the onset of Parkinson's disease in a subset of patients. Furthermore, the fact that the risk of essential tremor is significantly increased in relatives of patients with Parkinson's disease suggests the possibility that both conditions are genetically related, probably sharing common hereditary predisposition. Dopaminergic deficit among essential tremor patients in functional imaging studies and recent pathological studies describing Lewy bodies in some essential tremor patients, support further evidence for an overlap between both conditions, at least in a subset of patients.
CONCLUSION: The convergence of all the reviewed data suggests the possible existence of a mixed essential tremor-Parkinson's disease phenotype in some patients. However, further studies are needed to better understand this phenotype.
Andrés Labiano-Fontcuberta; Julián Benito-León
Publication Detail:
Type:  English Abstract; Journal Article; Review    
Journal Detail:
Title:  Revista de neurologia     Volume:  55     ISSN:  1576-6578     ISO Abbreviation:  Rev Neurol     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-11     Completed Date:  2013-04-05     Revised Date:  2013-04-19    
Medline Journal Info:
Nlm Unique ID:  7706841     Medline TA:  Rev Neurol     Country:  Spain    
Other Details:
Languages:  spa     Pagination:  479-89     Citation Subset:  IM    
Servicio de Neurología, Hospital Universitario 12 de Octubre, Madrid, España.
Vernacular Title:
Temblor esencial y enfermedad de Parkinson: ¿existe una asociación?
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MeSH Terms
Age Factors
Depression / epidemiology,  etiology
Disease Progression
Essential Tremor / complications*,  epidemiology,  genetics,  pathology,  physiopathology
Genetic Predisposition to Disease
Lewy Bodies / ultrastructure
Locus Coeruleus / pathology
Membrane Proteins / genetics
Middle Aged
Nerve Tissue Proteins / genetics
Parkinson Disease / complications*,  epidemiology,  genetics,  pathology,  physiopathology,  psychology
Parkinsonian Disorders / epidemiology
Tremor / classification,  epidemiology
Reg. No./Substance:
0/LINGO1 protein, human; 0/Membrane Proteins; 0/Nerve Tissue Proteins
Comment In:
Rev Neurol. 2013 Mar 16;56(6):351-2   [PMID:  23483474 ]
Rev Neurol. 2013 Mar 16;56(6):351   [PMID:  23483473 ]
Rev Neurol. 2013 Mar 16;56(6):350-1   [PMID:  23483472 ]

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