| Essential thrombocythemia with myelofibrosis transformed into acute myeloid leukemia with der(1;15)(q10;q10): case report and literature review. | |
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MedLine Citation:
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PMID: 20513531 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Translocations involving chromosomes 1 and 15 are uncommon in hematologic malignancies. So far, only 42 cases have been reported with t(1;15) as a reciprocal or complex chromosomal abnormalities. We herein report the first case in the literature, to our knowledge, of a 44-year-old female with essential thrombocythemia and severe myelofibrosis who developed acute myeloid leukemia (AML-M4) with der(1;15)(q10;q10) after 13 years of treatment. In addition, we reviewed the literature for all up-to-date published cases with t(1;15). |
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Authors:
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Khalil M Charafeddine; Rami A Mahfouz; Ghazi S Zaatari; Georges Y Ibrahim; Samar A Muwakkit; Nada D Najm; Chantal G Farra |
Publication Detail:
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Type: Case Reports; Journal Article; Review |
Journal Detail:
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Title: Cancer genetics and cytogenetics Volume: 200 ISSN: 1873-4456 ISO Abbreviation: Cancer Genet. Cytogenet. Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-06-01 Completed Date: 2010-06-17 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7909240 Medline TA: Cancer Genet Cytogenet Country: United States |
Other Details:
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Languages: eng Pagination: 28-33 Citation Subset: IM |
Copyright Information:
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2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Pathology and Laboratory Medicine, American University of Beirut Medical Center, Lebanon. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Chromosome Aberrations Chromosomes, Human, Pair 11* Chromosomes, Human, Pair 15* Female Humans Leukemia, Myeloid, Acute / genetics* Primary Myelofibrosis / genetics* Thrombocythemia, Essential / genetics* |
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