Document Detail

Essential thrombocythemia with myelofibrosis transformed into acute myeloid leukemia with der(1;15)(q10;q10): case report and literature review.
MedLine Citation:
PMID:  20513531     Owner:  NLM     Status:  MEDLINE    
Translocations involving chromosomes 1 and 15 are uncommon in hematologic malignancies. So far, only 42 cases have been reported with t(1;15) as a reciprocal or complex chromosomal abnormalities. We herein report the first case in the literature, to our knowledge, of a 44-year-old female with essential thrombocythemia and severe myelofibrosis who developed acute myeloid leukemia (AML-M4) with der(1;15)(q10;q10) after 13 years of treatment. In addition, we reviewed the literature for all up-to-date published cases with t(1;15).
Khalil M Charafeddine; Rami A Mahfouz; Ghazi S Zaatari; Georges Y Ibrahim; Samar A Muwakkit; Nada D Najm; Chantal G Farra
Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Cancer genetics and cytogenetics     Volume:  200     ISSN:  1873-4456     ISO Abbreviation:  Cancer Genet. Cytogenet.     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-06-01     Completed Date:  2010-06-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7909240     Medline TA:  Cancer Genet Cytogenet     Country:  United States    
Other Details:
Languages:  eng     Pagination:  28-33     Citation Subset:  IM    
Copyright Information:
2010 Elsevier Inc. All rights reserved.
Department of Pathology and Laboratory Medicine, American University of Beirut Medical Center, Lebanon.
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MeSH Terms
Chromosome Aberrations
Chromosomes, Human, Pair 11*
Chromosomes, Human, Pair 15*
Leukemia, Myeloid, Acute / genetics*
Primary Myelofibrosis / genetics*
Thrombocythemia, Essential / genetics*

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