Document Detail

Essential thrombocythemia presenting as localized livedo reticularis.
MedLine Citation:
PMID:  23542719     Owner:  NLM     Status:  In-Data-Review    
: Essential thrombocythemia is a chronic myeloproliferative disorder characterized by a persistent and absolute increase in the peripheral platelet count (>600,000/mm) in the absence of another underlying disorder. From a clinical point of view, it is characterized by thrombotic manifestations that primarily involve the central nervous system as strokes and transient ischemic attacks and also affects other systems, causing gastrointestinal hemorrhages and arterial or venous thrombosis. Cutaneous manifestations may complicate essential thrombocythemia, but they may be a helpful guide to the diagnosis. These manifestations appear up to 22% of patients and may even be the presenting sign of the disease in up to 10% of them. We present a case of a previously healthy woman who was diagnosed with essential thrombocythemia after the onset of localized livedo reticularis. The case was immunohistochemically studied, supporting the role of the increased platelet number in the pathogenesis of the livedo reticularis lesions.
Ursula Pielasinski; Rosario Haro; Carlos Santonja; Heinz Kutzner; Luis Requena
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American Journal of dermatopathology     Volume:  35     ISSN:  1533-0311     ISO Abbreviation:  Am J Dermatopathol     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-04-01     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7911005     Medline TA:  Am J Dermatopathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e22-5     Citation Subset:  IM    
*Department of Dermatology †Department of Pathology, Fundación Jiménez Diaz, Universidad Autónoma, Madrid, Spain ‡Dermatophatologische Gemeinschaftslabor, Friedrichshafen, Germany.
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