Document Detail

Essential mixed cryoglobulinemia type II.
MedLine Citation:
PMID:  16870105     Owner:  NLM     Status:  MEDLINE    
We report a rare case of essential mixed cryoglobulinemia type II with membrano-proliferative glomerulonephritis (MPGN) type I in which HCV was not found. Long-term history of palindromic rheumatism, skin leukocytoclastic vasculitis attacks and micro-normocytic anemia preceded the appearance of cryoglobulinemia. Cryoprecipitate consisted of monoclonal IgMk-RF and polyclonal IgG (essential mixed type II). The newly appreciated cryoglobulinemia was associated with Coombs positive hemolytic anemia. The MPGN in this case had a benign course and responded to complex simple therapies including prevention of exposure to cold, low antigen content diet, treatment of provoking factors such as UTI, and maximal dose of ACE inhibitor. Responsiveness of skin vasculitis to colchicine therapy was restored after a two-month colchicine withdrawal period and therefore corticosteroid and immunosuppressive therapy was postponed.
A P Rozin; M Lewin; Y Braun-Moscovici; O B Itzhak; R Bergman; A Balbir-Gurman
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Clinical and experimental rheumatology     Volume:  24     ISSN:  0392-856X     ISO Abbreviation:  Clin. Exp. Rheumatol.     Publication Date:    2006 May-Jun
Date Detail:
Created Date:  2006-07-27     Completed Date:  2006-11-14     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  8308521     Medline TA:  Clin Exp Rheumatol     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  329-32     Citation Subset:  IM    
The B. Shine Department of Rheumatology, Rambam Medical Center and B. Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.
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MeSH Terms
Anemia, Hemolytic / complications,  pathology*,  therapy
Angiotensin-Converting Enzyme Inhibitors / therapeutic use
Antigens / analysis
Antirheumatic Agents / therapeutic use
Colchicine / therapeutic use
Combined Modality Therapy
Coombs' Test
Cryoglobulinemia / complications,  pathology*
Drug Therapy, Combination
Food, Formulated / analysis
Glomerulonephritis, Membranoproliferative / complications,  pathology*,  therapy
Hydroxychloroquine / therapeutic use
Ramipril / therapeutic use
Treatment Outcome
Vasculitis, Leukocytoclastic, Cutaneous / etiology,  pathology*,  therapy
Reg. No./Substance:
0/Angiotensin-Converting Enzyme Inhibitors; 0/Antigens; 0/Antirheumatic Agents; 118-42-3/Hydroxychloroquine; 64-86-8/Colchicine; 87333-19-5/Ramipril

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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