Document Detail


Essential hypertension and risk of nephropathy: a reappraisal.
MedLine Citation:
PMID:  20051853     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE OF REVIEW: Treating mild-to-moderate essential hypertension in nondiabetic African Americans fails to halt nephropathy progression, whereas hypertension control slows nephropathy progression in European Americans. The pathogenesis of these disparate renal syndromes is reviewed.
RECENT FINDINGS: The nonmuscle myosin heavy chain 9 gene (MYH9) is associated with a spectrum of kidney diseases in African Americans, including idiopathic focal global glomerulosclerosis historically attributed to hypertension, idiopathic focal segmental glomerulosclerosis, and the collapsing variant of focal segmental glomerulosclerosis [HIV-associated nephropathy (HIVAN)]. Risk variants in MYH9 likely contribute to the failure of hypertension control to slow progressive kidney disease in nondiabetic African Americans.
SUMMARY: Early and intensive hypertension control fails to halt progression of 'hypertensive nephropathy' in African Americans. Genetic analyses in patients with essential hypertension and nephropathy attributed to hypertension, focal segmental glomerulosclerosis and HIVAN reveal that MYH9 gene polymorphisms are associated with a spectrum of kidney diseases in this ethnic group. Mild to moderate hypertension may cause nephropathy in European Americans with intrarenal vascular disease improved by the treatment of hypertension, hyperlipidemia and smoking cessation.
Authors:
Mariana Murea; Barry I Freedman
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Current opinion in nephrology and hypertension     Volume:  19     ISSN:  1473-6543     ISO Abbreviation:  Curr. Opin. Nephrol. Hypertens.     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-04-15     Completed Date:  2010-09-14     Revised Date:  2014-09-14    
Medline Journal Info:
Nlm Unique ID:  9303753     Medline TA:  Curr Opin Nephrol Hypertens     Country:  England    
Other Details:
Languages:  eng     Pagination:  235-41     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Disease Progression
Humans
Hypertension / ethnology*,  genetics*
Kidney Failure, Chronic / ethnology*,  genetics*,  prevention & control
Risk Factors
Grant Support
ID/Acronym/Agency:
R01 DK070941/DK/NIDDK NIH HHS; R01 DK070941/DK/NIDDK NIH HHS; R01 DK070941-04/DK/NIDDK NIH HHS; R01 DK084149/DK/NIDDK NIH HHS; R01 DK084149/DK/NIDDK NIH HHS; R01 DK084149-01/DK/NIDDK NIH HHS; R01 HL056266/HL/NHLBI NIH HHS; R01 HL056266-04/HL/NHLBI NIH HHS
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