Document Detail

Essential hypertension: improved differentiation by the temperature dependence of Li efflux in erythrocytes.
MedLine Citation:
PMID:  6581123     Owner:  NLM     Status:  MEDLINE    
Kinetic and thermodynamic properties of red cell lithium (Li) efflux were examined in patients with essential hypertension; the maximal rate of Li efflux as affected by temperature was measured at the range of 12 degrees to 42 degrees C. Fifty-two patients with essential hypertension and 22 normotensives were studied. The mean Li efflux, both into sodium (Na) medium and Li-Na countertransport, was higher in hypertensive than in normotensive persons, but the distinction between the two groups was limited by extended scatter and overlap. The distinction could be markedly improved by determining the effect of temperature on Li efflux. While all the normotensives exhibited Arrhenius plots of Li efflux with a change in slope ("break") around 30 degrees C, the corresponding "break" for most (75%) of the hypertensives was about 20 degrees C. Consideration of both the rate and the temperature dependence of Li efflux further improved the differentiation of hypertensive patients. Analysis of normotensive offspring of hypertensives and of patients with secondary hypertension indicates that the temperature dependence of Li efflux may serve as a genetic marker for essential hypertension.
R Levy; E Paran; A Keynan; A Livne
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Hypertension     Volume:  5     ISSN:  0194-911X     ISO Abbreviation:  Hypertension     Publication Date:    1983 Nov-Dec
Date Detail:
Created Date:  1984-02-14     Completed Date:  1984-02-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  821-7     Citation Subset:  IM    
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MeSH Terms
Biological Transport, Active
Cell Membrane Permeability
Erythrocyte Membrane / metabolism*
Genetic Markers
Hypertension / blood*,  genetics
Lithium / blood*
Middle Aged
Sodium / blood
Reg. No./Substance:
0/Genetic Markers; 7439-93-2/Lithium; 7440-23-5/Sodium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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