| Essential hypertension: improved differentiation by the temperature dependence of Li efflux in erythrocytes. | |
MedLine Citation:
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PMID: 6581123 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Kinetic and thermodynamic properties of red cell lithium (Li) efflux were examined in patients with essential hypertension; the maximal rate of Li efflux as affected by temperature was measured at the range of 12 degrees to 42 degrees C. Fifty-two patients with essential hypertension and 22 normotensives were studied. The mean Li efflux, both into sodium (Na) medium and Li-Na countertransport, was higher in hypertensive than in normotensive persons, but the distinction between the two groups was limited by extended scatter and overlap. The distinction could be markedly improved by determining the effect of temperature on Li efflux. While all the normotensives exhibited Arrhenius plots of Li efflux with a change in slope ("break") around 30 degrees C, the corresponding "break" for most (75%) of the hypertensives was about 20 degrees C. Consideration of both the rate and the temperature dependence of Li efflux further improved the differentiation of hypertensive patients. Analysis of normotensive offspring of hypertensives and of patients with secondary hypertension indicates that the temperature dependence of Li efflux may serve as a genetic marker for essential hypertension. |
Authors:
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R Levy; E Paran; A Keynan; A Livne |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Hypertension Volume: 5 ISSN: 0194-911X ISO Abbreviation: Hypertension Publication Date: 1983 Nov-Dec |
Date Detail:
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Created Date: 1984-02-14 Completed Date: 1984-02-14 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7906255 Medline TA: Hypertension Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 821-7 Citation Subset: IM |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Biological Transport, Active Cell Membrane Permeability Erythrocyte Membrane / metabolism* Female Genetic Markers Humans Hypertension / blood*, genetics Kinetics Lithium / blood* Male Middle Aged Sodium / blood Temperature |
| Chemical | |
Reg. No./Substance:
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0/Genetic Markers; 7439-93-2/Lithium; 7440-23-5/Sodium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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