| Essential hypertension: first reason for persistent hypertension after unilateral adrenalectomy for primary aldosteronism? | |
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MedLine Citation:
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PMID: 9854594 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Despite cure of primary aldosteronism by surgical resection, hypertension persists postoperatively in 30% to 50% of patients. The aim of this study was to determine factors influencing long-term outcome of blood pressure after unilateral adrenalectomy for primary aldosteronism. METHODS: Records of 100 patients who underwent unilateral adrenalectomy for primary aldosteronism from 1970 through 1997 were reviewed. Patients were distributed in 2 groups according to whether blood pressure was normal (criteria of World Health Organization). Clinical, biochemical, and pathologic data were compared. RESULTS: All patients were biochemically cured. Blood pressure was normal in 56 patients and improved in 44 (mean follow-up, 69 and 59 months). Persistent hypertension correlated with age, known duration and seriousness of preoperative hypertension, family history of hypertension, no preoperative response to spironolactone, and contralateral adrenal hypertrophy. Gender, surgical approach, and pathologic findings were not predictive factors of blood pressure outcome. The prevalence of hypertension was almost the same in these postoperative patients as the prevalence of essential hypertension in a random population of the same age. CONCLUSIONS: Early unilateral adrenalectomy allows cure or improvement of hypertension in all patients with primary aldosteronism induced by unilateral excessive source of aldosterone secretion regardless of the pathologic findings. Persistent hypertension suggests that coexisting essential hypertension is present. |
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Authors:
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C A Proye; E A Mulliez; B M Carnaille; M Lecomte-Houcke; M Decoulx; J L Wémeau; J Lefebvre; A Racadot; O Ernst; D Huglo; A Carré |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Surgery Volume: 124 ISSN: 0039-6060 ISO Abbreviation: Surgery Publication Date: 1998 Dec |
Date Detail:
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Created Date: 1999-01-11 Completed Date: 1999-01-11 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0417347 Medline TA: Surgery Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1128-33 Citation Subset: AIM; IM |
Affiliation:
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Department of General and Endocrine Surgery, Lille University Hospital, France. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adrenalectomy* Adult Aged Female Follow-Up Studies Humans Hyperaldosteronism / complications, surgery* Hypertension / epidemiology, etiology, surgery* Male Middle Aged |
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