Document Detail

Essential hypertension: a disorder of growth with origins in childhood?
MedLine Citation:
PMID:  1313473     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To review evidence that essential hypertension is a growth-related disorder with origins in childhood and manifestations in adult life.
PRINCIPAL EVIDENCE: Blood pressure rises with age in children and adults. In children, the rise closely relates to growth and to skeletal and sexual maturation. Adolescents with highest pressure are heavier and had as children grown fastest; as adults, they show the greatest increase of pressure with age and are more likely to develop hypertension and coronary heart disease. In adults, the rate of increase of pressure relates to earlier pressure. One interpretation of this is that a self-perpetuating mechanism is at work. Genetic and environmental factors influence these events.
HYPOTHETICAL MECHANISMS: Most forms of secondary hypertension have two pressor mechanisms; a primary cause, e.g. renal clip, and a second process, which is slow to develop, capable of maintaining hypertension after removal of the primary cause, and probably self-perpetuating in nature. We suggest that essential hypertension also has two mechanisms, both based upon cardiovascular hypertrophy: (1) a growth-promoting process in children (equivalent to the primary cause in secondary hypertension); and (2) a self-perpetuating mechanism in adults.
A F Lever; S B Harrap
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Publication Detail:
Type:  Editorial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of hypertension     Volume:  10     ISSN:  0263-6352     ISO Abbreviation:  J. Hypertens.     Publication Date:  1992 Feb 
Date Detail:
Created Date:  1992-05-07     Completed Date:  1992-05-07     Revised Date:  2013-07-15    
Medline Journal Info:
Nlm Unique ID:  8306882     Medline TA:  J Hypertens     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  101-20     Citation Subset:  IM    
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MeSH Terms
Aging / physiology*
Blood Pressure / physiology*
Cardiomegaly / etiology
Gonadal Steroid Hormones / physiology
Growth Hormone / physiology
Hypertension / etiology*
Insulin / physiology
Insulin Resistance / physiology
Insulin-Like Growth Factor I / physiology
Rats, Inbred SHR
Reg. No./Substance:
0/Gonadal Steroid Hormones; 0/Insulin; 67763-96-6/Insulin-Like Growth Factor I; 9002-72-6/Growth Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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