| Essential fatty acids predict metabolites of serotonin and dopamine in cerebrospinal fluid among healthy control subjects, and early- and late-onset alcoholics. | |
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MedLine Citation:
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PMID: 9715354 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Impulsive violence, suicide, and depression are strongly associated with low concentrations of cerebrospinal fluid 5-hydroxyindoleacetic acid (CSF 5-HIAA). Increased suicide and trauma reported in some cholesterol-lowering trials may be related to altered concentrations of polyunsaturated fatty acids rather than cholesterol, a possible surrogate marker. METHODS: CSF 5-HIAA and homovanillic acid (HVA), total cholesterol, and plasma fatty acid concentrations were examined in 176 subjects, including 49 healthy volunteers, and 88 early- and 39 late-onset alcoholics. RESULTS: Among each group, polyunsaturated fatty acids predicted both CSF 5-HIAA and CSF HVA concentrations, but total cholesterol was unrelated to either neurotransmitter metabolite. The relationships between plasma 22: 6n3 and CSF 5-HIAA were significantly different when healthy volunteers (r = .35) were compared to early-onset alcoholics (r = -.38) (p < .0002). CONCLUSIONS: Dietary studies are indicated to determine if essential fatty acid supplementation can influence central nervous system serotonin and dopamine metabolism and modify impulsive behaviors related to these neurotransmitters. |
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Authors:
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J R Hibbeln; M Linnoila; J C Umhau; R Rawlings; D T George; N Salem |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Biological psychiatry Volume: 44 ISSN: 0006-3223 ISO Abbreviation: Biol. Psychiatry Publication Date: 1998 Aug |
Date Detail:
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Created Date: 1998-11-12 Completed Date: 1998-11-12 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0213264 Medline TA: Biol Psychiatry Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 235-42 Citation Subset: IM |
Affiliation:
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Laboratory of Membrane Biochemistry and Biophysics, National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Age of Onset Alcoholism / cerebrospinal fluid, classification, metabolism* Biological Markers / blood, cerebrospinal fluid Case-Control Studies Cholesterol / blood Cross-Sectional Studies Docosahexaenoic Acids / blood Dopamine / metabolism* Fatty Acids, Unsaturated / blood* Female Homovanillic Acid / cerebrospinal fluid* Humans Hydroxyindoleacetic Acid / cerebrospinal fluid* Male Middle Aged Regression Analysis Serotonin / metabolism* Statistics, Nonparametric |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Fatty Acids, Unsaturated; 25167-62-8/Docosahexaenoic Acids; 306-08-1/Homovanillic Acid; 50-67-9/Serotonin; 54-16-0/Hydroxyindoleacetic Acid; 57-88-5/Cholesterol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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