Document Detail

Essential fatty acids predict metabolites of serotonin and dopamine in cerebrospinal fluid among healthy control subjects, and early- and late-onset alcoholics.
MedLine Citation:
PMID:  9715354     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Impulsive violence, suicide, and depression are strongly associated with low concentrations of cerebrospinal fluid 5-hydroxyindoleacetic acid (CSF 5-HIAA). Increased suicide and trauma reported in some cholesterol-lowering trials may be related to altered concentrations of polyunsaturated fatty acids rather than cholesterol, a possible surrogate marker. METHODS: CSF 5-HIAA and homovanillic acid (HVA), total cholesterol, and plasma fatty acid concentrations were examined in 176 subjects, including 49 healthy volunteers, and 88 early- and 39 late-onset alcoholics. RESULTS: Among each group, polyunsaturated fatty acids predicted both CSF 5-HIAA and CSF HVA concentrations, but total cholesterol was unrelated to either neurotransmitter metabolite. The relationships between plasma 22: 6n3 and CSF 5-HIAA were significantly different when healthy volunteers (r = .35) were compared to early-onset alcoholics (r = -.38) (p < .0002). CONCLUSIONS: Dietary studies are indicated to determine if essential fatty acid supplementation can influence central nervous system serotonin and dopamine metabolism and modify impulsive behaviors related to these neurotransmitters.
J R Hibbeln; M Linnoila; J C Umhau; R Rawlings; D T George; N Salem
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Biological psychiatry     Volume:  44     ISSN:  0006-3223     ISO Abbreviation:  Biol. Psychiatry     Publication Date:  1998 Aug 
Date Detail:
Created Date:  1998-11-12     Completed Date:  1998-11-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0213264     Medline TA:  Biol Psychiatry     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  235-42     Citation Subset:  IM    
Laboratory of Membrane Biochemistry and Biophysics, National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland, USA.
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MeSH Terms
Age of Onset
Alcoholism / cerebrospinal fluid,  classification,  metabolism*
Biological Markers / blood,  cerebrospinal fluid
Case-Control Studies
Cholesterol / blood
Cross-Sectional Studies
Docosahexaenoic Acids / blood
Dopamine / metabolism*
Fatty Acids, Unsaturated / blood*
Homovanillic Acid / cerebrospinal fluid*
Hydroxyindoleacetic Acid / cerebrospinal fluid*
Middle Aged
Regression Analysis
Serotonin / metabolism*
Statistics, Nonparametric
Reg. No./Substance:
0/Biological Markers; 0/Fatty Acids, Unsaturated; 25167-62-8/Docosahexaenoic Acids; 306-08-1/Homovanillic Acid; 50-67-9/Serotonin; 54-16-0/Hydroxyindoleacetic Acid; 57-88-5/Cholesterol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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