| Essential fatty acids, lipid membrane abnormalities, and the diagnosis and treatment of schizophrenia. | |
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MedLine Citation:
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PMID: 10650444 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Recent research suggests that deficient uptake or excessive breakdown of membrane phospholipids may be associated with schizophrenia. We review available clinical research on abnormalities in membrane fatty acid composition and metabolism in schizophrenia, and therapeutic trials of fatty acid in this disorder. All potentially relevant English-language articles were identified from the medical and psychiatric literature with the aid of computer searches using key words such as lipids, phospholipids, prostaglandins and schizophrenia. All studies which include human subjects are reviewed. Empirical studies related to membrane hypotheses of schizophrenia focus on: 1) assessment of prostaglandins (PG) and their essential fatty acid (EFA) precursors in the tissues of patients with schizophrenia; 2) evaluation of the niacin flush test as a possible diagnostic marker; 3) evaluation of phospholipase enzyme activity; 4) NMR spectroscopy studies of brain phospholipid metabolism; and 5) therapeutic trials of PG precursors for the treatment of schizophrenia. The most consistent clinical findings include red blood cell fatty acid membrane abnormalities, NMR spectroscopy evidence of increased phospholipid turnover and a therapeutic effect of omega-3 fatty acid supplementation of neuroleptic treatment in some schizophrenia patients. Studies of EFA metabolism have proved fruitful for generating and testing novel etiologic hypotheses and new therapeutic agents for schizophrenia. Greater attention to factors that influence tissue EFA levels such as diet, tobacco and alcohol are required to reconcile inconsistent findings. Treatment studies, although promising, require independent replication. |
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Authors:
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W S Fenton; J Hibbeln; M Knable |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Biological psychiatry Volume: 47 ISSN: 0006-3223 ISO Abbreviation: Biol. Psychiatry Publication Date: 2000 Jan |
Date Detail:
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Created Date: 2000-03-08 Completed Date: 2000-03-08 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 0213264 Medline TA: Biol Psychiatry Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 8-21 Citation Subset: IM |
Affiliation:
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Stanley Treatment Programs at Chestnut Lodge, Bethesda (MK), Maryland, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Biological Markers Brain / metabolism* Fatty Acids, Essential / metabolism, therapeutic use* Fatty Acids, Omega-3 / metabolism, therapeutic use Fatty Acids, Omega-6 Fatty Acids, Unsaturated / metabolism, therapeutic use Humans Magnetic Resonance Spectroscopy Membrane Lipids / metabolism* Phospholipids / metabolism Prostaglandins / metabolism Schizophrenia / diagnosis, metabolism*, therapy |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Fatty Acids, Essential; 0/Fatty Acids, Omega-3; 0/Fatty Acids, Omega-6; 0/Fatty Acids, Unsaturated; 0/Membrane Lipids; 0/Phospholipids; 0/Prostaglandins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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