| Essential fatty acids in tissue phospholipids and triglycerides of the zinc-deficient rat. | |
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MedLine Citation:
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PMID: 6440147 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study addressed the possibility that zinc deficiency has different effects on the fatty acid composition of triglyceride compared to total phospholipid. Male weanling Sprague-Dawley rats were maintained for 6 weeks on a semisynthetic diet deficient in zinc (3 mg/kg zinc). Control rats (40 mg/kg zinc) were pair-fed. Lipid fractionation and fatty acid analysis were by thin-layer and gas chromatography, respectively. In zinc-deficient rats, the percentage of linoleic acid was increased or that of arachidonic acid was decreased in total phospholipids of plasma, liver, and testis, and in skin total lipids. Saturated and monounsaturated fatty acids were increased in the triglyceride of liver but decreased in the triglyceride of epididymal fat of zinc deficient rats. Essential fatty acids, as a proportion of total fatty acids, were decreased in triglyceride of liver but increased in triglyceride of epididymal fat of zinc-deficient rats. Our fatty acid data from tissue total phospholipids therefore support the concept that linoleic acid desaturation is impaired in zinc deficiency. |
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Authors:
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S C Cunnane; D F Horrobin; M S Manku |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) Volume: 177 ISSN: 0037-9727 ISO Abbreviation: Proc. Soc. Exp. Biol. Med. Publication Date: 1984 Dec |
Date Detail:
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Created Date: 1985-02-04 Completed Date: 1985-02-04 Revised Date: 2007-11-02 |
Medline Journal Info:
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Nlm Unique ID: 7505892 Medline TA: Proc Soc Exp Biol Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 441-6 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adipose Tissue
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metabolism Animals Arachidonic Acid Arachidonic Acids / metabolism Fatty Acids / metabolism Fatty Acids, Essential / metabolism* Linoleic Acid Linoleic Acids / metabolism Liver / metabolism Male Phospholipids / blood, metabolism* Rats Rats, Inbred Strains Skin / metabolism Testis / metabolism Triglycerides / metabolism* Zinc / deficiency* |
| Chemical | |
Reg. No./Substance:
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0/Arachidonic Acids; 0/Fatty Acids; 0/Fatty Acids, Essential; 0/Linoleic Acids; 0/Phospholipids; 0/Triglycerides; 2197-37-7/Linoleic Acid; 506-32-1/Arachidonic Acid; 7440-66-6/Zinc |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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