Document Detail

Essential fatty acids in tissue phospholipids and triglycerides of the zinc-deficient rat.
MedLine Citation:
PMID:  6440147     Owner:  NLM     Status:  MEDLINE    
This study addressed the possibility that zinc deficiency has different effects on the fatty acid composition of triglyceride compared to total phospholipid. Male weanling Sprague-Dawley rats were maintained for 6 weeks on a semisynthetic diet deficient in zinc (3 mg/kg zinc). Control rats (40 mg/kg zinc) were pair-fed. Lipid fractionation and fatty acid analysis were by thin-layer and gas chromatography, respectively. In zinc-deficient rats, the percentage of linoleic acid was increased or that of arachidonic acid was decreased in total phospholipids of plasma, liver, and testis, and in skin total lipids. Saturated and monounsaturated fatty acids were increased in the triglyceride of liver but decreased in the triglyceride of epididymal fat of zinc deficient rats. Essential fatty acids, as a proportion of total fatty acids, were decreased in triglyceride of liver but increased in triglyceride of epididymal fat of zinc-deficient rats. Our fatty acid data from tissue total phospholipids therefore support the concept that linoleic acid desaturation is impaired in zinc deficiency.
S C Cunnane; D F Horrobin; M S Manku
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)     Volume:  177     ISSN:  0037-9727     ISO Abbreviation:  Proc. Soc. Exp. Biol. Med.     Publication Date:  1984 Dec 
Date Detail:
Created Date:  1985-02-04     Completed Date:  1985-02-04     Revised Date:  2007-11-02    
Medline Journal Info:
Nlm Unique ID:  7505892     Medline TA:  Proc Soc Exp Biol Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  441-6     Citation Subset:  IM    
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MeSH Terms
Adipose Tissue / metabolism
Arachidonic Acid
Arachidonic Acids / metabolism
Fatty Acids / metabolism
Fatty Acids, Essential / metabolism*
Linoleic Acid
Linoleic Acids / metabolism
Liver / metabolism
Phospholipids / blood,  metabolism*
Rats, Inbred Strains
Skin / metabolism
Testis / metabolism
Triglycerides / metabolism*
Zinc / deficiency*
Reg. No./Substance:
0/Arachidonic Acids; 0/Fatty Acids; 0/Fatty Acids, Essential; 0/Linoleic Acids; 0/Phospholipids; 0/Triglycerides; 2197-37-7/Linoleic Acid; 506-32-1/Arachidonic Acid; 7440-66-6/Zinc

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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