| Essential fatty acids and dietary stress. | |
| | |
MedLine Citation:
|
PMID: 19651798 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
There are two families of essential fatty acids that must be obtained from the diet: the omega-6 fatty acids consisting of linoleic and arachidonic acids and the omega-3 fatty acids consisting of linolenic, eicosapentaenoic and docosahexaenoic acids (Prog Chem Fats Other Lipids 1968:9;275-348; Recent Pat Cardiovasc Drug Discov 2007; 2:13-21; Mini Rev Med Chem 2008; 8:107-115). Vegetables and vegetable oils are sources of linoleic and linolenic acids, and the higher omega-3s are obtained from fish. The estimated ratio of omega-6:omega-3 fatty acids in the typical Western diet is about 20:1, whereas, several lines of evidence indicate that a ration of 1:1 would be optimal. Both series of fatty acids can be oxidatively metabolized to a range of products. The oxidative metabolites of arachidonic acid are all proinflammatory and/or prothrombotic, while the corresponding omega-3 metabolites are anti-inflammatory and/or antithrombotic. The imbalanced consumption of the two families of essential fatty acids contributes to a range of diseases. Greater awareness of this problem is leading to increased use of dietary supplements and new products intended to decrease omega-6 consumption while increasing omega-3 intake. |
| | |
Authors:
|
P W Wertz |
Related Documents
:
|
15108178 - Association of a long-chain fatty acid-coa ligase 4 gene polymorphism with depression a... 9241888 - Fatty acid compositions of colostrum, cord blood, maternal blood and major infant formu... 2404668 - Dietary immunomodulation: beneficial effects on oncogenesis and tumor growth. 20089728 - Associations of very high intakes of eicosapentaenoic and docosahexaenoic acids with bi... 19461948 - An acid- and base-stable o-nitrobenzyl photolabile linker for solid phase organic synth... 12228898 - Development of a new assay for the screening of hypochlorous acid scavengers based on r... |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Review |
Journal Detail:
|
Title: Toxicology and industrial health Volume: 25 ISSN: 0748-2337 ISO Abbreviation: Toxicol Ind Health Publication Date: 2009 May-Jun |
Date Detail:
|
Created Date: 2009-08-04 Completed Date: 2009-10-19 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8602702 Medline TA: Toxicol Ind Health Country: England |
Other Details:
|
Languages: eng Pagination: 279-83 Citation Subset: IM |
Affiliation:
|
University of Iowa, Iowa City IA, USA. Philip-wertz@uiowa.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Diet* Fatty Acids, Essential / metabolism* Fatty Acids, Omega-3 / metabolism* Humans |
| Grant Support | |
ID/Acronym/Agency:
|
R01 DE018032/DE/NIDCR NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Fatty Acids, Essential; 0/Fatty Acids, Omega-3 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Signaling pathways involved in phase II gene induction by alpha, beta-unsaturated aldehydes.
Next Document: Extra virgin olive oil phenolics: absorption, metabolism, and biological activities in the GI tract.