Document Detail


Essential fatty acids and dietary stress.
MedLine Citation:
PMID:  19651798     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
There are two families of essential fatty acids that must be obtained from the diet: the omega-6 fatty acids consisting of linoleic and arachidonic acids and the omega-3 fatty acids consisting of linolenic, eicosapentaenoic and docosahexaenoic acids (Prog Chem Fats Other Lipids 1968:9;275-348; Recent Pat Cardiovasc Drug Discov 2007; 2:13-21; Mini Rev Med Chem 2008; 8:107-115). Vegetables and vegetable oils are sources of linoleic and linolenic acids, and the higher omega-3s are obtained from fish. The estimated ratio of omega-6:omega-3 fatty acids in the typical Western diet is about 20:1, whereas, several lines of evidence indicate that a ration of 1:1 would be optimal. Both series of fatty acids can be oxidatively metabolized to a range of products. The oxidative metabolites of arachidonic acid are all proinflammatory and/or prothrombotic, while the corresponding omega-3 metabolites are anti-inflammatory and/or antithrombotic. The imbalanced consumption of the two families of essential fatty acids contributes to a range of diseases. Greater awareness of this problem is leading to increased use of dietary supplements and new products intended to decrease omega-6 consumption while increasing omega-3 intake.
Authors:
P W Wertz
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Toxicology and industrial health     Volume:  25     ISSN:  0748-2337     ISO Abbreviation:  Toxicol Ind Health     Publication Date:    2009 May-Jun
Date Detail:
Created Date:  2009-08-04     Completed Date:  2009-10-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8602702     Medline TA:  Toxicol Ind Health     Country:  England    
Other Details:
Languages:  eng     Pagination:  279-83     Citation Subset:  IM    
Affiliation:
University of Iowa, Iowa City IA, USA. Philip-wertz@uiowa.edu
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MeSH Terms
Descriptor/Qualifier:
Diet*
Fatty Acids, Essential / metabolism*
Fatty Acids, Omega-3 / metabolism*
Humans
Grant Support
ID/Acronym/Agency:
R01 DE018032/DE/NIDCR NIH HHS
Chemical
Reg. No./Substance:
0/Fatty Acids, Essential; 0/Fatty Acids, Omega-3

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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