Document Detail

Essential fatty acids deficiency promotes lipogenic gene expression and hepatic steatosis through the Liver X Receptor.
MedLine Citation:
PMID:  23333450     Owner:  NLM     Status:  Publisher    
BACKGROUND & AIMS: Nutrients influence non alcoholic fatty liver disease. Essential fatty acids deficiency promotes various syndromes including hepatic steatosis through increased de novo lipogenesis. The mechanisms underlying such increased lipogenic response remain unidentified. METHODS: We used wild-type mice and mice lacking Liver X Receptors to perform a nutrigenomic study that aimed at examining the role of these transcription factors. RESULTS: We showed that, in the absence of Liver X Receptors, essential fatty acids deficiency does not promote steatosis. Consistent with this, Liver X Receptors are required for the elevated expression of genes involved in lipogenesis in response to essential fatty acids deficiency. CONCLUSION: This work identifies for the first time the central role of Liver X Receptors in steatosis induced by essential fatty acids deficiency.
Simon Ducheix; Alexandra Montagner; Arnaud Polizzi; Frédéric Lasserre; Alice Marmugi; Justine Bertrand-Michel; Normand Podechard; Talal Al Saati; Maud Chétiveaux; Silvère Baron; Jérôme Boué; Gilles Dietrich; Laila Mselli-Lakhal; Philippe Costet; Jean-Marc A Lobaccaro; Thierry Pineau; Vassilia Theodorou; Catherine Postic; Pascal G P Martin; Hervé Guillou
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-15
Journal Detail:
Title:  Journal of hepatology     Volume:  -     ISSN:  1600-0641     ISO Abbreviation:  J. Hepatol.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8503886     Medline TA:  J Hepatol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2013. Published by Elsevier B.V.
INRA, TOXALIM (Research Centre in Food Toxicology), Toulouse, France; Université de Toulouse, INP, UPS, TOXALIM, Toulouse, France.
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