| Essential fatty acid status and fluidity of plasma phospholipids in cystic fibrosis infants. | |
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MedLine Citation:
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PMID: 1957818 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The fatty acid (FA) patterns of cord serum phospholipids (PLs) were examined in 4 cystic fibrosis (CF) newborns, 8 non-CF siblings, and 22 normal control subjects. Plasma from 27 newly diagnosed CF infants and 38 normal infants aged less than 2 y were studied for comparison. CF cord-blood PLs had patterns similar to those of CF siblings and to normal newborns, but the pattern for CF did not shift toward adult patterns during infancy as did patterns for normal infants. CF infants at diagnosis exhibited a deficiency pattern in which 18: 2 omega 6, 20:4 omega 6, 22:4 omega 6, an omega 3 polyunsaturated fatty acids (PUFAs) were significantly subnormal and 18:3 omega 6, total saturated fatty acids, and total monounsaturated fatty acids were significantly elevated compared with normal infants. In PLs in CF infants, although mean chain length of FAs was low, mean melting point was elevated 2.4 degrees C and double-bond index was low (both P less than 0.001), implying a significantly lessened fluidity. Nutritional supplements of both omega 6 and omega 3 PUFAs are cated. |
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Authors:
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J D Lloyd-Still; S B Johnson; R T Holman |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The American journal of clinical nutrition Volume: 54 ISSN: 0002-9165 ISO Abbreviation: Am. J. Clin. Nutr. Publication Date: 1991 Dec |
Date Detail:
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Created Date: 1992-01-02 Completed Date: 1992-01-02 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0376027 Medline TA: Am J Clin Nutr Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1029-35 Citation Subset: AIM; IM |
Affiliation:
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Division of Gastroenterology, Children's Memorial Hospital, Northwestern University, Chicago, IL 60614. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aging
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blood Cystic Fibrosis / blood*, genetics Fatty Acids, Essential / blood* Fatty Acids, Unsaturated / blood Fetal Blood Humans Infant Infant, Newborn Phospholipids / blood*, physiology Reference Values |
| Grant Support | |
ID/Acronym/Agency:
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AM34931/AM/NIADDK NIH HHS; HL08214/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Fatty Acids, Essential; 0/Fatty Acids, Unsaturated; 0/Phospholipids |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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