Document Detail


Essential fatty acid status and fluidity of plasma phospholipids in cystic fibrosis infants.
MedLine Citation:
PMID:  1957818     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The fatty acid (FA) patterns of cord serum phospholipids (PLs) were examined in 4 cystic fibrosis (CF) newborns, 8 non-CF siblings, and 22 normal control subjects. Plasma from 27 newly diagnosed CF infants and 38 normal infants aged less than 2 y were studied for comparison. CF cord-blood PLs had patterns similar to those of CF siblings and to normal newborns, but the pattern for CF did not shift toward adult patterns during infancy as did patterns for normal infants. CF infants at diagnosis exhibited a deficiency pattern in which 18: 2 omega 6, 20:4 omega 6, 22:4 omega 6, an omega 3 polyunsaturated fatty acids (PUFAs) were significantly subnormal and 18:3 omega 6, total saturated fatty acids, and total monounsaturated fatty acids were significantly elevated compared with normal infants. In PLs in CF infants, although mean chain length of FAs was low, mean melting point was elevated 2.4 degrees C and double-bond index was low (both P less than 0.001), implying a significantly lessened fluidity. Nutritional supplements of both omega 6 and omega 3 PUFAs are cated.
Authors:
J D Lloyd-Still; S B Johnson; R T Holman
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  54     ISSN:  0002-9165     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  1991 Dec 
Date Detail:
Created Date:  1992-01-02     Completed Date:  1992-01-02     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1029-35     Citation Subset:  AIM; IM    
Affiliation:
Division of Gastroenterology, Children's Memorial Hospital, Northwestern University, Chicago, IL 60614.
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MeSH Terms
Descriptor/Qualifier:
Aging / blood
Cystic Fibrosis / blood*,  genetics
Fatty Acids, Essential / blood*
Fatty Acids, Unsaturated / blood
Fetal Blood
Humans
Infant
Infant, Newborn
Phospholipids / blood*,  physiology
Reference Values
Grant Support
ID/Acronym/Agency:
AM34931/AM/NIADDK NIH HHS; HL08214/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Fatty Acids, Essential; 0/Fatty Acids, Unsaturated; 0/Phospholipids

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