Document Detail

Essential-fatty-acid metabolites in plasma phospholipids in patients with ichthyosis vulgaris, acne vulgaris and psoriasis.
MedLine Citation:
PMID:  2142029     Owner:  NLM     Status:  MEDLINE    
The concentration of essential fatty acids (EFAs) and their metabolites in plasma phospholipids were measured by gas chromatography in normal individuals, and in patients with ichthyosis vulgaris, acne vulgaris or psoriasis. In all three patient groups, concentrations of arachidonic acid (20:4 omega 6) and docosapentaenoic acid (22:5 omega 6) were significantly below those in controls, suggesting that these abnormalities may occur in many skin diseases. Concentrations of dihomogammalinolenic acid (20:3 omega 6) were low in ichthyosis, normal in acne and elevated in psoriasis. Thus ichthyosis, acne and psoriasis each had a characteristic pattern of EFA metabolites.
C Grattan; J L Burton; M Manku; C Stewart; D F Horrobin
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Clinical and experimental dermatology     Volume:  15     ISSN:  0307-6938     ISO Abbreviation:  Clin. Exp. Dermatol.     Publication Date:  1990 May 
Date Detail:
Created Date:  1990-08-16     Completed Date:  1990-08-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7606847     Medline TA:  Clin Exp Dermatol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  174-6     Citation Subset:  IM    
Department of Dermatology, General Hospital, Birmingham, UK.
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MeSH Terms
Acne Vulgaris / blood*
Chromatography, Gas
Chromatography, Thin Layer
Fatty Acids, Essential / blood*,  metabolism
Ichthyosis / blood*
Middle Aged
Phospholipids / blood*
Psoriasis / blood*
Reg. No./Substance:
0/Fatty Acids, Essential; 0/Phospholipids

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