| Essential-fatty-acid metabolites in plasma phospholipids in patients with ichthyosis vulgaris, acne vulgaris and psoriasis. | |
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MedLine Citation:
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PMID: 2142029 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The concentration of essential fatty acids (EFAs) and their metabolites in plasma phospholipids were measured by gas chromatography in normal individuals, and in patients with ichthyosis vulgaris, acne vulgaris or psoriasis. In all three patient groups, concentrations of arachidonic acid (20:4 omega 6) and docosapentaenoic acid (22:5 omega 6) were significantly below those in controls, suggesting that these abnormalities may occur in many skin diseases. Concentrations of dihomogammalinolenic acid (20:3 omega 6) were low in ichthyosis, normal in acne and elevated in psoriasis. Thus ichthyosis, acne and psoriasis each had a characteristic pattern of EFA metabolites. |
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Authors:
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C Grattan; J L Burton; M Manku; C Stewart; D F Horrobin |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Clinical and experimental dermatology Volume: 15 ISSN: 0307-6938 ISO Abbreviation: Clin. Exp. Dermatol. Publication Date: 1990 May |
Date Detail:
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Created Date: 1990-08-16 Completed Date: 1990-08-16 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7606847 Medline TA: Clin Exp Dermatol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 174-6 Citation Subset: IM |
Affiliation:
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Department of Dermatology, General Hospital, Birmingham, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acne Vulgaris
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blood* Adolescent Adult Aged Chromatography, Gas Chromatography, Thin Layer Fatty Acids, Essential / blood*, metabolism Female Humans Ichthyosis / blood* Male Middle Aged Phospholipids / blood* Psoriasis / blood* |
| Chemical | |
Reg. No./Substance:
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0/Fatty Acids, Essential; 0/Phospholipids |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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