Document Detail

Essential fatty acid deficiency profiles in idiopathic immunoglobulin A nephropathy.
MedLine Citation:
PMID:  8172206     Owner:  NLM     Status:  MEDLINE    
The profiles of fatty acids (FAs) of plasma phospholipids (the compartment reflecting the essential FA status of tissue lipids), nonesterified FAs (the precursor pool for autacoid synthesis), urine protein excretion, and glomerular filtration rate were measured before and after supplementation with fish oil in 15 patients with immunoglobulin A nephropathy. In the FA profiles, there was deficient 18:3 omega 3 (alpha-linolenic acid), the parent compound of omega 3 polyunsaturated FA, and deficient chain elongation products of both omega 3 and omega 6 polyunsaturated FAs with replacement by saturated and monounsaturated short-chain, odd-chain, and branched-chain FAs, producing significant loss of omega 3 FA. These alterations indicate nutritional or functional (omega 3) and metabolic (omega 6) deficiencies. Additionally, the mean melting point of the FAs was significantly increased, implying an inherent decrease in cell membrane fluidity. Enhancement of 20: 5 omega 3 (eicosapentaenoic acid) and 22:6 omega 3 (docosahexaenoic acid) and suppression of 20:4 omega 6 (arachidonate) after supplementation with fish oil were accompanied by important decreases in proteinuria and improved glomerular filtration rate. Omega-3 polyunsaturated FAs may favorably influence immunoglobulin A nephropathy through a modulation of the pathologic actions of the omega 6 eicosanoids and other diverse actions on various mediators produced by an initial immune injury.
R T Holman; S B Johnson; D Bibus; D C Spencer; J V Donadio
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Publication Detail:
Type:  Clinical Trial; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of kidney diseases : the official journal of the National Kidney Foundation     Volume:  23     ISSN:  0272-6386     ISO Abbreviation:  Am. J. Kidney Dis.     Publication Date:  1994 May 
Date Detail:
Created Date:  1994-05-27     Completed Date:  1994-05-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8110075     Medline TA:  Am J Kidney Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  648-54     Citation Subset:  IM    
Hormel Institute, University of Minnesota, Austin.
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MeSH Terms
Deficiency Diseases / blood,  complications
Fatty Acids, Essential / blood,  deficiency*
Fatty Acids, Nonesterified / blood*
Fatty Acids, Omega-3 / administration & dosage*
Glomerulonephritis, IGA / blood,  complications*
Middle Aged
Phospholipids / blood*
Reg. No./Substance:
0/Fatty Acids, Essential; 0/Fatty Acids, Nonesterified; 0/Fatty Acids, Omega-3; 0/Phospholipids

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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