Document Detail


Essential fatty acid deficiency: probing the role of arachidonate in biology.
MedLine Citation:
PMID:  2144697     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
EFA deficiency appears to be a uniquely useful tool in probing the role of arachidonate in a variety of physiologic and pathologic processes. Recent studies have clarified the effects of the deficiency state on tissue fatty acid content and on the production of metabolites of arachidonate and related mediators such as PAF. The ability of EFA deficiency to ameliorate a variety of inflammatory states, particularly models of autoimmune disease, is striking. The central mechanism appears to be the ability of EFA deficiency to inhibit leukocyte migration into foci of inflammation. The mechanisms underlying this phenomenon are currently under investigation. Additionally EFA deficiency has the capacity to alter dramatically tissue immunogenicity by affecting the representation of Ia-bearing cells within tissues. The role of arachidonate in the regulation of Ia-bearing cells within tissues is an area of continuing interest.
Authors:
J B Lefkowith
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Advances in prostaglandin, thromboxane, and leukotriene research     Volume:  20     ISSN:  0732-8141     ISO Abbreviation:  Adv. Prostaglandin Thromboxane Leukot. Res.     Publication Date:  1990  
Date Detail:
Created Date:  1990-10-16     Completed Date:  1990-10-16     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8211444     Medline TA:  Adv Prostaglandin Thromboxane Leukot Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  224-31     Citation Subset:  IM    
Affiliation:
Div. of Rheumatology, Washington University School of Medicine, St. Louis, MO 63110.
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MeSH Terms
Descriptor/Qualifier:
Animals
Arachidonic Acid
Arachidonic Acids / metabolism*
Fatty Acids, Essential / deficiency*
Inflammation / immunology
Lipid Metabolism
Prostaglandins / biosynthesis
Grant Support
ID/Acronym/Agency:
AI-27457/AI/NIAID NIH HHS; DK-37879/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Arachidonic Acids; 0/Fatty Acids, Essential; 0/Prostaglandins; 506-32-1/Arachidonic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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