| Essential fatty acid deficiency: probing the role of arachidonate in biology. | |
| | |
MedLine Citation:
|
PMID: 2144697 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
EFA deficiency appears to be a uniquely useful tool in probing the role of arachidonate in a variety of physiologic and pathologic processes. Recent studies have clarified the effects of the deficiency state on tissue fatty acid content and on the production of metabolites of arachidonate and related mediators such as PAF. The ability of EFA deficiency to ameliorate a variety of inflammatory states, particularly models of autoimmune disease, is striking. The central mechanism appears to be the ability of EFA deficiency to inhibit leukocyte migration into foci of inflammation. The mechanisms underlying this phenomenon are currently under investigation. Additionally EFA deficiency has the capacity to alter dramatically tissue immunogenicity by affecting the representation of Ia-bearing cells within tissues. The role of arachidonate in the regulation of Ia-bearing cells within tissues is an area of continuing interest. |
| | |
Authors:
|
J B Lefkowith |
Related Documents
:
|
3129587 - Fatty acid profiles in response to soybean oil lipid emulsion infusions in essential fa... 9451797 - The lipoxygenase sensor, a new approach in essential fatty acid determination in foods. 835507 - Phenylalanine-tyrosine deficiency syndrome as a complication of the management of hered... 5342397 - Response of log-phase cells of escherichia coli to medium limited in both sulfate and p... 9070617 - Synthesis of 4- and 5-series leukotrienes in the lung microvasculature challenged with ... 15957917 - Cu(oac)2-catalyzed n-arylations of sulfoximines with aryl boronic acids. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
|
Title: Advances in prostaglandin, thromboxane, and leukotriene research Volume: 20 ISSN: 0732-8141 ISO Abbreviation: Adv. Prostaglandin Thromboxane Leukot. Res. Publication Date: 1990 |
Date Detail:
|
Created Date: 1990-10-16 Completed Date: 1990-10-16 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 8211444 Medline TA: Adv Prostaglandin Thromboxane Leukot Res Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 224-31 Citation Subset: IM |
Affiliation:
|
Div. of Rheumatology, Washington University School of Medicine, St. Louis, MO 63110. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Arachidonic Acid Arachidonic Acids / metabolism* Fatty Acids, Essential / deficiency* Inflammation / immunology Lipid Metabolism Prostaglandins / biosynthesis |
| Grant Support | |
ID/Acronym/Agency:
|
AI-27457/AI/NIAID NIH HHS; DK-37879/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Arachidonic Acids; 0/Fatty Acids, Essential; 0/Prostaglandins; 506-32-1/Arachidonic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Structure-function relationships in sheep, mouse, and human prostaglandin endoperoxide G/H synthases...
Next Document: Biosynthesis and functions of leukotriene C4.