| Essential fatty acid deficiency and postresection mucosal adaptation in the rat. | |
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MedLine Citation:
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PMID: 3338636 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effect of short-term (biochemical) and long-term (clinical) essential fatty acid (EFA) deficiency on mucosal adaptation was studied in a surgical model of short bowel syndrome. Rats fed an EFA-deficient diet for 4 wk had biochemical evidence of EFA deficiency (hepatic and red blood cell triene to tetraene ratios greater than 0.4). Resected animals (70% proximal jejunoileal resection) receiving an EFA-deficient diet had a significantly impaired intestinal mucosal hyperplasia response in all remaining small bowel segments compared with resected controls. The effect of refeeding a control diet to clinically EFA-deficient resected rats was also evaluated. Short-term refeeding (2 wk) of a control diet resulted in a significant return toward normal tissue triene to tetraene ratios. Concomitantly, refed animals had significantly greater mucosal adaptation in the remaining duodenal/jejunal segment compared with resected animals maintained on an EFA-deficient diet postoperatively. These experiments underscore the dynamic nature of tissue EFA status and the importance of fatty acids in the normal compensatory mechanisms of mucosal adaptation after resection. |
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Authors:
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M H Hart; C J Grandjean; J H Park; S H Erdman; J A Vanderhoof |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Gastroenterology Volume: 94 ISSN: 0016-5085 ISO Abbreviation: Gastroenterology Publication Date: 1988 Mar |
Date Detail:
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Created Date: 1988-03-11 Completed Date: 1988-03-11 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0374630 Medline TA: Gastroenterology Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 682-7 Citation Subset: AIM; IM |
Affiliation:
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Division of Pediatric Gastroenterology and Nutrition, University of Nebraska Medical Center, Omaha. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adaptation, Physiological Animals Erythrocytes / analysis Fatty Acids, Essential / analysis, deficiency* Intestinal Mucosa / metabolism* Intestine, Small / metabolism*, surgery Liver / analysis, cytology Male Rats |
| Chemical | |
Reg. No./Substance:
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0/Fatty Acids, Essential |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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