Document Detail

Essential fatty acid deficiency during total parenteral nutrition.
MedLine Citation:
PMID:  6782957     Owner:  NLM     Status:  MEDLINE    
Essential fatty acid (EFA) deficiency has become a clinical problem since the advent of fat-free total parenteral nutrition (TPN). The following study was done to determine the minimum fat requirements for patients receiving continuous TPN solution. Seventy-seven patients who had 97 courses of TPN of at least 14 days duration were prospectively studied. The following fat supplementation was given: a) none, b) 10% soybean oil emulsion intravenously at fixed dosage, c) fat from an oral diet, or d) intravenous and oral fat. No patient was EFA deficient before the onset of TPN. EFA deficiency was prevented when at least 3.2% of total calories were given as intravenous fat or at least 15% as oral fat. Lesser amounts of fat decreased the rate of EFA deficiency development but did not prevent it from occurring. The 7.7 g/day of linoleic acid provided in 1000 ml per week of 10% soybean oil emulsion provides adequate fat to prevent EFA deficiency.
L H Barr; G D Dunn; M F Brennan
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of surgery     Volume:  193     ISSN:  0003-4932     ISO Abbreviation:  Ann. Surg.     Publication Date:  1981 Mar 
Date Detail:
Created Date:  1981-05-13     Completed Date:  1981-05-13     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0372354     Medline TA:  Ann Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  304-11     Citation Subset:  AIM; IM    
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MeSH Terms
8,11,14-Eicosatrienoic Acid / blood
Arachidonic Acids / blood
Dietary Fats / administration & dosage
Energy Intake
Fat Emulsions, Intravenous / therapeutic use
Fatty Acids, Essential / deficiency*
Middle Aged
Nutritional Requirements
Parenteral Nutrition / adverse effects*
Parenteral Nutrition, Total / adverse effects*,  methods
Prospective Studies
Reg. No./Substance:
0/Arachidonic Acids; 0/Dietary Fats; 0/Fat Emulsions, Intravenous; 0/Fatty Acids, Essential; 2751-14-6/mead acid; 7324-41-6/8,11,14-Eicosatrienoic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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