Document Detail

Essential characteristics of antibiotics for the treatment of seriously ill patients.
MedLine Citation:
PMID:  7326692     Owner:  NLM     Status:  MEDLINE    
To realize their full potential for effective therapy in critically ill patients, antimicrobial agents must share three essential characteristics, namely in vivo as well as in vitro effectiveness, lack of toxicity, and reasonable cost. In vitro activity depends on the ability of the antimicrobial agent to reach its microbial target site and to overcome various mechanisms of resistance in the infecting organism. Although there is a general correlation between in vitro effectiveness and in vivo utility, this is not always true. In addition to having in vitro activity against the infecting organism, effective drugs must penetrate to the site of infection and must retain significant activity at that location. Antimicrobial agents ideally should be nontoxic at all dose levels and should not be metabolized to toxic intermediates. Direct toxicity (adverse effects) is often relatively easy to assess, but antimicrobial agents may also produce subtle abnormalities in host defense mechanisms that are more difficult to assess. In addition to the market price of a given antimicrobial agent, one must also consider the cost of monitoring for the treatment of adverse effects.
R C Moellering
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical therapeutics     Volume:  4 Suppl A     ISSN:  0149-2918     ISO Abbreviation:  Clin Ther     Publication Date:  1981  
Date Detail:
Created Date:  1982-04-20     Completed Date:  1982-04-20     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7706726     Medline TA:  Clin Ther     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1-7     Citation Subset:  IM    
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MeSH Terms
Anti-Bacterial Agents / adverse effects,  pharmacology,  therapeutic use*
Bacteria / drug effects
Bacterial Infections / drug therapy*
Costs and Cost Analysis
Drug Resistance, Microbial
Reg. No./Substance:
0/Anti-Bacterial Agents

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