Document Detail


Essential role of estrogen for improvements in vascular endothelial function with endurance exercise in postmenopausal women.
MedLine Citation:
PMID:  24092827     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: In contrast to age-matched men, endurance exercise training is not consistently associated with enhanced endothelial function in estrogen-deficient postmenopausal women. We determined whether endurance exercise training improves endothelial function in postmenopausal women treated with estrogen. In a substudy, we determined if oxidative stress is mechanistically linked to endothelial function adaptations to endurance exercise training.
PARTICIPANTS AND DESIGN: Brachial artery flow-mediated dilation (FMD) was measured in 36 sedentary, estrogen-deficient postmenopausal women (45-65 y) at study entry (baseline), after 12 weeks of either placebo, oral (1 mg/d) estradiol, or transdermal estradiol (0.05 mg/d) (randomized), and after an additional 12 weeks of continued estradiol or placebo treatment with concurrent endurance exercise training. In subgroups of women, FMD also was measured during the infusion of ascorbic acid at baseline and following estradiol/placebo plus endurance exercise training, and in seven habitually endurance-trained estrogen-deficient controls.
RESULTS: FMD increased in the estrogen-treated groups (both P < .01) after 12 weeks and remained unchanged in placebo. FMD further increased following 12 weeks of endurance exercise training in estrogen-treated (both P < .025), but not placebo-treated women (P = .55). In the substudy, baseline FMD was similar between sedentary and endurance-trained controls. Ascorbic acid increased FMD at baseline in sedentary women and endurance-trained controls, and following endurance exercise training in placebo-treated, but not in estrogen-treated women.
CONCLUSIONS: Estrogen status appears to play an important modulatory role in improvements in endothelial function with endurance exercise training in postmenopausal women. The restored endurance exercise training adaptation in estrogen-treated postmenopausal women may be related to mitigation of oxidative stress.
Authors:
Kerrie L Moreau; Brian L Stauffer; Wendy M Kohrt; Douglas R Seals
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural     Date:  2013-10-03
Journal Detail:
Title:  The Journal of clinical endocrinology and metabolism     Volume:  98     ISSN:  1945-7197     ISO Abbreviation:  J. Clin. Endocrinol. Metab.     Publication Date:  2013 Nov 
Date Detail:
Created Date:  2013-11-06     Completed Date:  2014-01-02     Revised Date:  2014-11-04    
Medline Journal Info:
Nlm Unique ID:  0375362     Medline TA:  J Clin Endocrinol Metab     Country:  United States    
Other Details:
Languages:  eng     Pagination:  4507-15     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Administration, Cutaneous
Administration, Oral
Adult
Aged
Brachial Artery / physiology
Endothelium, Vascular / drug effects,  physiology*
Estradiol / administration & dosage*,  deficiency,  physiology*
Estrogen Replacement Therapy / methods
Exercise / physiology*
Female
Humans
Oxidative Stress / drug effects,  physiology
Physical Endurance / drug effects,  physiology*
Postmenopause / drug effects,  physiology*
Sedentary Lifestyle
Grant Support
ID/Acronym/Agency:
AG013038/AG/NIA NIH HHS; K01AG020683/AG/NIA NIH HHS; P30 DK048520/DK/NIDDK NIH HHS; R01AG022241/AG/NIA NIH HHS; R01AG027678/AG/NIA NIH HHS; UL1-RR-025780/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
4TI98Z838E/Estradiol
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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