Document Detail

Esophagopharyngeal distribution of refluxed gastric acid in patients with reflux laryngitis.
MedLine Citation:
PMID:  7557141     Owner:  NLM     Status:  MEDLINE    
BACKGROUND & AIMS: A variety of otolaryngological abnormalities have been attributed to the contact of gastroesophageal refluxate with respective structures of the aerodigestive tract. The aim of this study was to determine and compare the pharyngoesophageal distribution of gastric acid refluxate between patients with proven laryngitis attributed clinically to gastroesophageal reflux and three control groups. METHODS: An ambulatory 24-hour simultaneous three-site pharyngoesophageal pH monitoring technique was used to measure reflux parameters in the pharynx, proximal esophagus, and distal esophagus. RESULTS: Between-group comparison showed no significant difference in the reflux parameters in the distal esophagus between the studied groups. A significantly higher percentage of distal reflux episodes reached the proximal esophagus in the laryngitis group than in the control groups (P < 0.01), and the number of pharyngeal reflux episodes and time of acid exposure were significantly higher in the laryngitis group than in the control groups (P < 0.001). CONCLUSIONS: Compared with normal controls and patients with gastroesophageal reflux disease, pharyngeal reflux of gastric acid is significantly more prevalent and the ratio of proximal to distal esophageal acid reflux episodes is significantly increased in patients with posterior laryngitis. Simultaneous three-site ambulatory pharyngoesophageal pH monitoring may provide supporting evidence when the diagnosis of reflux-induced aerodigestive tract lesions is considered.
R Shaker; M Milbrath; J Ren; R Toohill; W J Hogan; Q Li; C L Hofmann
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Gastroenterology     Volume:  109     ISSN:  0016-5085     ISO Abbreviation:  Gastroenterology     Publication Date:  1995 Nov 
Date Detail:
Created Date:  1995-11-21     Completed Date:  1995-11-21     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0374630     Medline TA:  Gastroenterology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1575-82     Citation Subset:  AIM; IM    
Medical College of Wisconsin Dysphagia Institute, Department of Medicine, Milwaukee, USA.
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MeSH Terms
Esophagus / metabolism*
Gastric Acid / metabolism*
Gastroesophageal Reflux / complications,  metabolism*
Hydrogen-Ion Concentration
Laryngitis / etiology,  metabolism*
Middle Aged
Monitoring, Physiologic
Pharynx / metabolism*
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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