Document Detail

Esophagogastric junction opening during relaxation distinguishes nonhernia reflux patients, hernia patients, and normal subjects.
MedLine Citation:
PMID:  14517784     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND AIMS: Flow across the esophagogastric junction (EGJ) is strongly related to opening dimensions. This study aimed to determine whether opening of the relaxed EGJ was altered in patients with gastroesophageal reflux disease (GERD). METHODS: Seven normal subjects (NL), 9 GERD patients without hiatus hernia (NHH), and 7 with hiatus hernia (HH) were studied. Cross-sectional area (CSA) of the relaxed EGJ was measured during low-pressure distention using a modified barostat technique that resulted in filling a compliant bag straddling the EGJ with renograffin to the set pressure. Swallows were imaged fluoroscopically at distensive pressures of 2-12 mm Hg. The diameter of the narrowest point of the EGJ in PA and lateral projections was measured from digitized images. CSA was determined as a function of intrabag pressure. RESULTS: The minimal EGJ opening aperture occurred at the diaphragmatic hiatus in all subjects. At pressures </=0 mm Hg, EGJ opening was observed only in HH patients, making it plausible for these patients to reflux during deglutitive relaxation. At pressures >0 mm Hg, there were significant increases in EGJ CSA both for HH and NHH compared with NL (P < 0.001) and for HH compared with NHH (P < 0.005). This difference may explain the diminished air/water discrimination seen during transient lower esophageal sphincter (LES) relaxation-associated reflux in GERD patients. CONCLUSIONS: Anatomic degradation of the EGJ distinguishes GERD patients from normal subjects, and these changes may impact on both the observed mechanisms of reflux and the constituents of reflux during transient LES relaxation. Therapy focused on EGJ compliance may benefit GERD patients.
John E Pandolfino; Guoxiang Shi; Brian Trueworthy; Peter J Kahrilas
Related Documents :
18437494 - Anal resting pressures at manometry correlate with the fecal incontinence severity inde...
879154 - Indomethacin and canine lower esophageal sphincter pressure.
7233084 - The effect of parietal cell vagotomy on gastrooesophageal function in duodenal ulcer pa...
20167874 - Upper esophageal sphincter during transient lower esophageal sphincter relaxation: effe...
9927374 - Response to inhaled nitric oxide in acute lung injury depends on distribution of pulmon...
12494284 - Captopril treatment reverses erectile dysfunction in male stroke prone spontaneously hy...
Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Gastroenterology     Volume:  125     ISSN:  0016-5085     ISO Abbreviation:  Gastroenterology     Publication Date:  2003 Oct 
Date Detail:
Created Date:  2003-09-30     Completed Date:  2003-10-30     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0374630     Medline TA:  Gastroenterology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1018-24     Citation Subset:  AIM; IM    
Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Diagnosis, Differential
Duodenogastric Reflux / diagnosis*,  physiopathology*
Esophagogastric Junction / physiopathology*
Hernia, Hiatal / diagnosis*,  physiopathology*
Grant Support
Reg. No./Substance:
Comment In:
Gastroenterology. 2003 Oct;125(4):1258-60   [PMID:  14517807 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Enteric involvement of severe acute respiratory syndrome-associated coronavirus infection.
Next Document:  Randomized, double-blind comparison of 4 mg/kg versus 2 mg/kg intravenous cyclosporine in severe ulc...