Document Detail


Esophagogastric junction opening during relaxation distinguishes nonhernia reflux patients, hernia patients, and normal subjects.
MedLine Citation:
PMID:  14517784     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND AND AIMS: Flow across the esophagogastric junction (EGJ) is strongly related to opening dimensions. This study aimed to determine whether opening of the relaxed EGJ was altered in patients with gastroesophageal reflux disease (GERD). METHODS: Seven normal subjects (NL), 9 GERD patients without hiatus hernia (NHH), and 7 with hiatus hernia (HH) were studied. Cross-sectional area (CSA) of the relaxed EGJ was measured during low-pressure distention using a modified barostat technique that resulted in filling a compliant bag straddling the EGJ with renograffin to the set pressure. Swallows were imaged fluoroscopically at distensive pressures of 2-12 mm Hg. The diameter of the narrowest point of the EGJ in PA and lateral projections was measured from digitized images. CSA was determined as a function of intrabag pressure. RESULTS: The minimal EGJ opening aperture occurred at the diaphragmatic hiatus in all subjects. At pressures </=0 mm Hg, EGJ opening was observed only in HH patients, making it plausible for these patients to reflux during deglutitive relaxation. At pressures >0 mm Hg, there were significant increases in EGJ CSA both for HH and NHH compared with NL (P < 0.001) and for HH compared with NHH (P < 0.005). This difference may explain the diminished air/water discrimination seen during transient lower esophageal sphincter (LES) relaxation-associated reflux in GERD patients. CONCLUSIONS: Anatomic degradation of the EGJ distinguishes GERD patients from normal subjects, and these changes may impact on both the observed mechanisms of reflux and the constituents of reflux during transient LES relaxation. Therapy focused on EGJ compliance may benefit GERD patients.
Authors:
John E Pandolfino; Guoxiang Shi; Brian Trueworthy; Peter J Kahrilas
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Gastroenterology     Volume:  125     ISSN:  0016-5085     ISO Abbreviation:  Gastroenterology     Publication Date:  2003 Oct 
Date Detail:
Created Date:  2003-09-30     Completed Date:  2003-10-30     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0374630     Medline TA:  Gastroenterology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1018-24     Citation Subset:  AIM; IM    
Affiliation:
Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Air
Compliance
Diagnosis, Differential
Duodenogastric Reflux / diagnosis*,  physiopathology*
Esophagogastric Junction / physiopathology*
Female
Hernia, Hiatal / diagnosis*,  physiopathology*
Humans
Male
Manometry
Pressure
Water
Grant Support
ID/Acronym/Agency:
K23 DK62170-01/DK/NIDDK NIH HHS; R01 DC00646/DC/NIDCD NIH HHS
Chemical
Reg. No./Substance:
7732-18-5/Water
Comments/Corrections
Comment In:
Gastroenterology. 2003 Oct;125(4):1258-60   [PMID:  14517807 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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