| Esophagitis in scleroderma. Prevalence and risk factors. | |
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MedLine Citation:
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PMID: 3491774 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Of 53 patients with scleroderma (43 women and 10 men) evaluated by esophagoscopy and biopsy, 32 (60%) had erosive esophagitis. Symptoms of heartburn and dysphagia were significantly more frequent in the patients who had erosive esophagitis but often were present in those without this condition. Abnormal motility characterized by loss of peristalsis in the distal esophagus was present in all patients with erosive esophagitis, including the 5 who were asymptomatic. No patient with normal esophageal motility had erosive esophagitis at endoscopy. The patients with erosive esophagitis also had significantly diminished lower esophageal sphincter pressures and increased frequency and duration of gastroesophageal reflux episodes. Stricture was present in 13 of 32 patients with erosive esophagitis and was absent in the other 21 patients. The duration of disease, rate of gastric emptying, and fungal smear and culture were not significantly different in those with or without esophagitis. Treatment of fungal infection for a month had little beneficial effect. The pattern of esophageal motility in scleroderma identifies high and low risk groups for esophagitis and stricture, and can be used to select those who require further investigation, irrespective of symptoms. |
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Authors:
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B J Zamost; J Hirschberg; A F Ippoliti; D E Furst; P J Clements; W M Weinstein |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Gastroenterology Volume: 92 ISSN: 0016-5085 ISO Abbreviation: Gastroenterology Publication Date: 1987 Feb |
Date Detail:
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Created Date: 1987-02-17 Completed Date: 1987-02-17 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0374630 Medline TA: Gastroenterology Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 421-8 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Candidiasis
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etiology Cross-Sectional Studies Esophagitis / etiology* Esophagus / physiopathology Female Gastric Emptying Humans Hydrogen-Ion Concentration Male Manometry Middle Aged Peristalsis Risk Scleroderma, Systemic / complications*, physiopathology |
| Grant Support | |
ID/Acronym/Agency:
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17328//PHS HHS; RR00865/RR/NCRR NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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