Document Detail

Esophageal ulcers associated with tetracycline therapy.
MedLine Citation:
PMID:  131867     Owner:  NLM     Status:  MEDLINE    
Esophageal ulceration has rarely been reported secondary to medicinal agents. we have treated three patients with esophageal ulceration associated with the ingestion of tetracycline or its derivative doxycycline. In light of the strong temporal relationship between taking the capsules and the onset of the esophageal ulceration, we believe that the capsules were the cause of the ulcers. We therefore recommend an alternative agent to tetracycline or doxycycline, if possible, for patients with any esophageal obstructive element. We also recommend that patients be cautioned not to take these drugs within one hour of going to bed.
T D Crowson; L H Head; W A Ferrante
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  JAMA     Volume:  235     ISSN:  0098-7484     ISO Abbreviation:  JAMA     Publication Date:  1976 Jun 
Date Detail:
Created Date:  1976-08-02     Completed Date:  1976-08-02     Revised Date:  2014-09-17    
Medline Journal Info:
Nlm Unique ID:  7501160     Medline TA:  JAMA     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  2747-8     Citation Subset:  AIM; IM    
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MeSH Terms
Acne Vulgaris / drug therapy
Antacids / therapeutic use
Doxycycline / adverse effects,  therapeutic use
Esophageal Diseases / chemically induced*
Tetracycline / adverse effects*,  therapeutic use
Ulcer / chemically induced*,  drug therapy
Urinary Tract Infections / drug therapy
Reg. No./Substance:
0/Antacids; F8VB5M810T/Tetracycline; N12000U13O/Doxycycline

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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