Document Detail

Esophageal ulcer and alendronate.
MedLine Citation:
PMID:  10349198     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To describe a case of esophageal ulcer associated with the use of alendronate. CASE REPORT: This is the fifth case ever described in the literature according to our bibliographic review. In our patient, the association between the drug and the esophageal lesions was masked by the presence of a hiatal hernia, potentially a cause of the esophageal lesion. The persistence of the lesions despite high doses of anti-reflux therapy called attention to the possibility of the relationship. The esophageal lesion healed soon after suspension of alendronate. DISCUSSION: The authors present a review of the literature and point to the need for diagnostic investigation, to suspend such a drug from patients who experience dyspeptic symptoms while using it.
A P Ferrari Júnior; S H Domingues
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  São Paulo medical journal = Revista paulista de medicina     Volume:  116     ISSN:  1516-3180     ISO Abbreviation:  Sao Paulo Med J     Publication Date:    1998 Nov-Dec
Date Detail:
Created Date:  1999-09-02     Completed Date:  1999-09-02     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  100897261     Medline TA:  Sao Paulo Med J     Country:  BRAZIL    
Other Details:
Languages:  eng     Pagination:  1882-4     Citation Subset:  IM    
Division of Gastroenterology, Universidade Federal de São Paulo/Escola Paulista de Medicina, Brazil.
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MeSH Terms
Alendronate / adverse effects*
Diagnosis, Differential
Esophageal Diseases / chemically induced*,  diagnosis
Gastroesophageal Reflux / diagnosis
Hernia, Hiatal / diagnosis
Middle Aged
Ulcer / chemically induced*,  diagnosis
Reg. No./Substance:

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