Document Detail

Esophageal squamous cell carcinoma characterized by extensive chondroid differentiation.
MedLine Citation:
PMID:  10886731     Owner:  NLM     Status:  MEDLINE    
A rare case of carcinoma characterized by extensive chondroid elements at a site of primary esophageal and metastatic lesion is reported. The patient was a 67-year-old man complaining of dysphagia due to an ulcerative lesion at the lower middle esophagus. He underwent irradiation treatment prior to surgery. Histologically, the tumor consisted of both carcinomatous and chondroid elements and had invaded deeply into the esophageal wall. The carcinomatous cells had gradually become chondroid cells embedded within an extensive extracellular matrix. In addition, the metastatic lesion showed findings similar to those of the primary lesion. Immunohistochemistry revealed that both carcinomatous and chondroid elements were immunostained with cytokeratin and epithelial membrane antigen, suggesting an epithelial nature to the chondroid cells. Conversely, only chondroid cells were positively stained for S-100 protein. Furthermore, bone morphogenetic proteins (BMP) were positive for chondroid cells and their surrounding carcinomatous cells. Given the apparent transition between carcinomatous and chondroid cells based on microscopy and immunohistochemical findings in the present case, we concluded that the chondroid cells were derived from carcinomatous cells. In addition, our findings suggest that BMP produced by carcinomatous cells lead to chondroid differentiation of the carcinoma cells.
T Sugai; M Oikawa; N Uesugi; W Habano; Y F Jiao; S I Nakamura; S Hatakeyama; M Suhara; K Hatafuku
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Pathology international     Volume:  50     ISSN:  1320-5463     ISO Abbreviation:  Pathol. Int.     Publication Date:  2000 Jun 
Date Detail:
Created Date:  2000-09-08     Completed Date:  2000-09-08     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9431380     Medline TA:  Pathol Int     Country:  AUSTRALIA    
Other Details:
Languages:  eng     Pagination:  514-9     Citation Subset:  IM    
Division of Pathology, Central Clinical Laboratory, Department of Clinical Pathology, School of Medicine, Iwate Medical University, Morioka, Japan.
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MeSH Terms
Bone Morphogenetic Proteins / analysis
Carcinoma, Squamous Cell / metabolism,  pathology*
Cell Differentiation
Chondrocytes / metabolism,  pathology*
Esophageal Neoplasms / metabolism,  pathology*
Keratins / analysis
Mucin-1 / analysis
S100 Proteins / analysis
Reg. No./Substance:
0/Bone Morphogenetic Proteins; 0/Mucin-1; 0/S100 Proteins; 68238-35-7/Keratins

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