Document Detail

Esophageal sensation and esophageal hypersensitivity - overview from bench to bedside.
MedLine Citation:
PMID:  21103417     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Noxious stimuli in the esophagus activate nociceptive receptors on esophageal mucosa, such as transient receptor potential, acid-sensing ion channel and the P2X family, a family of ligand-gated ion channels responsive to ATP, and this generates signals that are transmitted to the central nervous system via either spinal nerves or vagal nerves, resulting in esophageal sensation. Among the noxious stimuli, gastric acid and other gastric contents are clinically most important, causing typical reflux symptoms such as heartburn and regurgitation. A conventional acid penetration theory has been used to explain the mechanism of heartburn, but much recent evidence does not support this theory. Therefore, it may be necessary to approach the causes of heartburn symptoms from a new conceptual framework. Hypersensitivity of the esophagus, like that of other visceral organs, includes peripheral, central and probably psychosocial factor-mediated hypersensitivity, and is known to play crucial roles in the pathoegenesis of nonerosive reflux disease, functional heartburn and non-cardiac chest pain. There also are esophagitis patients who do not perceive typical symptoms. This condition is known as silent gastroesophageal reflux disease. Although the pathogenesis of silent gastroesophageal reflux disease is still not known, hyposensitivity to reflux of acid may possibly explain the condition.
Hiroto Miwa; Takashi Kondo; Tadayuki Oshima; Hirokazu Fukui; Toshihiko Tomita; Jiro Watari
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Publication Detail:
Type:  Journal Article     Date:  2010-10-30
Journal Detail:
Title:  Journal of neurogastroenterology and motility     Volume:  16     ISSN:  2093-0887     ISO Abbreviation:  J Neurogastroenterol Motil     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-11-24     Completed Date:  2011-07-14     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  101530189     Medline TA:  J Neurogastroenterol Motil     Country:  Korea (South)    
Other Details:
Languages:  eng     Pagination:  353-62     Citation Subset:  -    
Division of Upper Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, Hyogo, Japan.
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