Document Detail


ESOPHAGEAL MOTOR ABNORMALITIES IN EOSINOPHILIC ESOPHAGITIS IDENTIFIED BY HIGH-RESOLUTION MANOMETRY.
MedLine Citation:
PMID:  21575059     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND: Esophageal motility abnormalities, as measured by conventional manometry (CM), are non-specific in the majority of patients with eosinophilic esophagitis (EoE). Moreover, the study with CM is limited by poor inter-observer agreement. AIMS: Firstly to asses the esophageal patterns in EoE by topographic analysis of high-resolution manometry (HRM) data; secondly, to establish a relationship between motility abnormalities and symptoms of EoE such as dysphagia and bolus impaction. METHODS: All adult patients with EoE diagnosed by histological criteria, and controls with gastroesophageal reflux disease symptoms and dysphagia, were included. HRM was done in EoE patients and controls. To the analysis of data, the Chicago classification was followed. RESULTS: HRM was performed in 21 patients with EoE, as well as in 21 controls. Of the 21 patients with EoE, 10 (48%) showed pan-oesophageal pressurization, 6 (28%) peristaltic dysfunction and in 5 (24%) cases HRM was normal. There was no pan-oesophageal pressurization in controls. Nine of ten patients with pan-oesophageal pressurization required endoscopic bolus removal (p < 0.05); none of them had obstructive endoscopy findings. CONCLUSIONS: The most frequent esophageal motor abnormality measured by HRM was a pan-oesophageal pressurization. Bolus impaction in patients with EoE was associated with pan-oesophageal pressurization.
Authors:
Leticia Martín Martín; Santander Cecilio; Lopez Martín Mari Carmen; Jorge Espinoza-Ríos; C Chavarría-Herbozo; Jp Gisbert; Ricardo Moreno-Otero
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-5-17
Journal Detail:
Title:  Journal of gastroenterology and hepatology     Volume:  -     ISSN:  1440-1746     ISO Abbreviation:  -     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-5-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8607909     Medline TA:  J Gastroenterol Hepatol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2011 Journal of Gastroenterology and Hepatology Foundation and Blackwell Publishing Asia Pty Ltd.
Affiliation:
Department of Gastroenterology and Hepatology, Universidad del País Vasco. Hospital Donostia, San Sebastián, Spain. Department of Gastroenterology and Hepatology, Motility Unit, La Princesa University Hospital. Universidad Autónoma de Madrid. Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD). Madrid, Spain.
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