Document Detail


Esophageal manometry in familial amyloid polyneuropathy.
MedLine Citation:
PMID:  4014307     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The motility of the esophagus was studied by esophageal manometry in eight patients with familial amyloid polyneuropathy. All eight patients had an abnormality of the lower esophageal sphincter. Seven of eight had a borderline or decreased lower esophageal sphincter pressure and the other patient had a non-relaxing lower esophageal sphincter pressure. Six of eight patients had abnormalities of the body of the esophagus consisting of either simultaneous or decreased amplitude of contractions involving the smooth or striated muscle or both. In addition, seven of eight patients had diarrhea and six of these seven patients had evidence for steatorrhea. The manometric abnormalities observed were consistent with deposition of amyloid in smooth and striated muscle as well as in the enteric nervous system. Esophageal manometry appears to be a sensitive technique to determine if the gastrointestinal tract is involved in familial amyloid polyneuropathy.
Authors:
R Burakoff; A Rubinow; A S Cohen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of medicine     Volume:  79     ISSN:  0002-9343     ISO Abbreviation:  Am. J. Med.     Publication Date:  1985 Jul 
Date Detail:
Created Date:  1985-08-09     Completed Date:  1985-08-09     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0267200     Medline TA:  Am J Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  85-9     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Amyloidosis / genetics,  physiopathology*
Esophagogastric Junction / physiopathology
Esophagus / physiopathology*
Female
Gastrointestinal Motility
Humans
Male
Manometry
Middle Aged
Nervous System Diseases / genetics,  physiopathology*
Pharynx / physiopathology
Grant Support
ID/Acronym/Agency:
AM-04599/AM/NIADDK NIH HHS; AM-07014/AM/NIADDK NIH HHS; AM-20613/AM/NIADDK NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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