Document Detail


Esophageal lichen planus: the Mayo Clinic experience.
MedLine Citation:
PMID:  10770369     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Lichen planus (LP) is an inflammatory papulosquamous disease which may affect the squamous epithelium of the esophagus. We reviewed six patients with esophageal lichen planus (ELP) seen at Mayo Clinic Rochester between 1984 and 1998. The presenting symptoms were dysphagia (in all six patients) and odynophagia (two patients). Cervical esophageal strictures were seen in four patients; average number of esophageal dilatations required was 15 (range, 10-18). Esophageal biopsies demonstrated the classical histologic findings of ELP in two patients, and a lymphocytic infiltrate in the other four. Concomitant lichen planus (LP) was seen at other sites in five patients: all five had oral LP preceeded by ELP symptoms in all five; three had genital LP preceeded by ELP symptoms in all three; two had dermal LP, preceeded by ELP symptoms in one. Proton pump inhibitors were tried unsuccessfully in all patients. Four patients were started on systemic steroid medication; three had resolution of symptoms within 1 month.
Authors:
G C Harewood; J A Murray; A J Cameron
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus / I.S.D.E     Volume:  12     ISSN:  1120-8694     ISO Abbreviation:  Dis. Esophagus     Publication Date:  1999  
Date Detail:
Created Date:  2000-05-17     Completed Date:  2000-05-17     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8809160     Medline TA:  Dis Esophagus     Country:  AUSTRALIA    
Other Details:
Languages:  eng     Pagination:  309-11     Citation Subset:  IM    
Affiliation:
Dept of Gastroenterology, Mayo Clinic Rochester, MN 55905, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Biopsy, Needle
Esophageal Diseases / diagnosis*,  drug therapy*,  pathology
Esophagoscopy
Female
Glucocorticoids / administration & dosage*
Hospitals, University
Humans
Lichen Planus / diagnosis*,  drug therapy*,  pathology
Middle Aged
Minnesota
Prednisone / administration & dosage*
Prognosis
Retrospective Studies
Treatment Outcome
Chemical
Reg. No./Substance:
0/Glucocorticoids; 53-03-2/Prednisone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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