Document Detail

Esophageal involvement as an initial manifestation of Churg-Strauss syndrome.
MedLine Citation:
PMID:  17261449     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION: Churg-Strauss syndrome (CSS) is a systemic disease characterized by asthma, blood and tissue eosinophilia, and necrotizing vasculitis with extravascular eosinophilic granulomas. CASES: We describe two cases of patients with CSS: a 56-year-old man, whose presentation was highly unusual because its initial predominant manifestation was odynophagia, and a 35-year-old man whose disease was diagnosed after a work-up because of nausea, vomiting and abdominal pain. In both cases, thoracic computerized tomography scans showed congestive esophagitis with a markedly thickened esophageal wall at diagnosis and at relapse. Both the vasculitis and the esophageal involvement improved with treatment. DISCUSSION: Gastrointestinal (GI) involvement is frequent in CSS patients and is one of the major causes of death associated with CSS. Nonetheless, eosinophilic vasculitis-related esophagitis is very rare.
Olivier Mir; Eve-Marie Nazal; Pascal Cohen; Olivier Vignaux; Alain Krivitzky; Boyan Christoforov; Raymond Jian; Luc Mouthon; Loïc Guillevin
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2006-12-13
Journal Detail:
Title:  Presse médicale (Paris, France : 1983)     Volume:  36     ISSN:  0755-4982     ISO Abbreviation:  Presse Med     Publication Date:  2007 Jan 
Date Detail:
Created Date:  2007-01-30     Completed Date:  2007-03-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8302490     Medline TA:  Presse Med     Country:  France    
Other Details:
Languages:  eng     Pagination:  57-60     Citation Subset:  IM    
Service de Médecine Interne, Centre de Référence Maladies Rares, Hôpital Cochin, AP-HP, Université Paris Descartes, Paris.
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MeSH Terms
Abdominal Pain / etiology
Churg-Strauss Syndrome / diagnosis*
Deglutition Disorders / etiology
Esophagitis / etiology*
Middle Aged
Nausea / etiology
Vomiting / etiology

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