| Esophageal epithelium of women with AIDS: thickness and local immunity. | |
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MedLine Citation:
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PMID: 20097482 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim of this study was to evaluate the morphological characteristics of the esophageal epithelium (EE) and its local immunity. Esophageal fragments of autopsied women were collected from 1980 to 2008, and two groups were analyzed: with AIDS (n=17) and without AIDS (n=12). The measurement of the esophageal epithelium was carried out through the image analysis software ImageJ, and the immunostaining of Langerhans cells (LCs) was carried out using anti-S100 antibody. Women with AIDS, when compared with women without AIDS, had significantly thinner EE (220.6 versus 243.5 microm), a less number of LCs (6.2 versus 18.8 LCs/mm(2)), and a higher percentage of immature or morphologically altered LCs (66.6 versus 40.0%). The malnourished women, when compared with normonourished women, regardless of AIDS, had significantly thinner EE (227.1 versus 238.0 microm) and a less number of LCs (6.2 versus 12.5 LCs/mm(2)). The percentage of immature or morphologically altered LCs was the same in both groups. Additionally, the women with AIDS (7.0 versus 2.8%) and the malnourished women (5.8 versus 3.1%) presented a significantly higher percentage of fibrosis. We concluded that AIDS and malnutrition contribute to the decrease in esophagus local immunity and, therefore, to a possible increase in local opportunistic infections. |
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Authors:
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Laura Rocha; Renata Silva; Jana?nna Oleg?rio; Rosana Corr?a; Vicente Teixeira; Camila Cavellani |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-01-25 |
Journal Detail:
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Title: Pathology, research and practice Volume: 206 ISSN: 1618-0631 ISO Abbreviation: Pathol. Res. Pract. Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-04-05 Completed Date: 2010-06-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7806109 Medline TA: Pathol Res Pract Country: Germany |
Other Details:
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Languages: eng Pagination: 248-52 Citation Subset: IM |
Copyright Information:
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Copyright 2009 Elsevier GmbH. All rights reserved. |
Affiliation:
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General Pathology Division, Tri?ngulo Mineiro Federal University, Uberaba, Minas Gerais, Brazil. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acquired Immunodeficiency Syndrome
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immunology*,
pathology*,
virology Adolescent Adult Atrophy / immunology, pathology, virology Cell Count Epithelium / immunology, pathology, virology Esophagus / immunology*, pathology*, virology Female Humans Image Processing, Computer-Assisted Immunity / immunology Langerhans Cells / immunology*, pathology, virology Middle Aged Nutritional Status / immunology Organ Size Statistics, Nonparametric |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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