| Esophageal dysmotility and gastroesophageal reflux in intrinsic asthma. | |
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MedLine Citation:
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PMID: 9201082 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study was undertaken to determine the prevalence of esophageal motor abnormalities, the incidence of gastroesophageal reflux, and the coexistence of gastroesophageal reflux with esophageal dysmotility in patients with intrinsic asthma. Based on clinical criteria, 34 consecutive asthmatics, 15 patients with gastroesophageal reflux, and 10 subjects with upper gastrointestinal symptoms with normal results of esophageal manometry and 24-hr esophageal pH test (controls) were studied. Esophageal motor disorders were noted in 23 of 34 asthmatics, and in 10 of 15 patients with acid reflux but in none of the subjects of the control group. A positive result of the prolonged esophageal pH study (pH in the distal esophagus less than 4 for more than 4.2% of the recording time) was obtained in 14 of 17 patients with asthma (only 17 of the original patients were tested because the others did not give informed consence for this test) and in all patients with gastroesophageal reflux. None of the members of the control group had positive test results. The findings of this study show that: (1) it is possible to identify a group of subjects with nonallergic asthma presenting with esophageal dysmotility, (2) the 24-hr esophageal pH study must be properly done in such patients; (3) esophageal motor abnormalities are often associated with positive pH results; and (4) more reflux was observed while in a supine position (especially during the night) than that observed either in control or reflux patients. Based on these results, patients with intrinsic asthma with reflux can benefit from both acid suppressive and prokinetic drugs with notable clinical implications regarding standard treatment for asthma, and those with prevalent supine compared to upright reflux could even benefit from surgery. |
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Authors:
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S Campo; S Morini; M A Re; D Monno; R Lorenzetti; B Moscatelli; E Bologna |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Digestive diseases and sciences Volume: 42 ISSN: 0163-2116 ISO Abbreviation: Dig. Dis. Sci. Publication Date: 1997 Jun |
Date Detail:
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Created Date: 1997-07-16 Completed Date: 1997-07-16 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7902782 Medline TA: Dig Dis Sci Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1184-8 Citation Subset: AIM; IM |
Affiliation:
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Divisione di Medicina, Ospedale S. Giovanni Calibita, Fatebenefratelli, Rome, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Asthma
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complications*,
epidemiology Case-Control Studies Esophageal Motility Disorders / complications*, diagnosis, epidemiology Female Gastroesophageal Reflux / complications*, diagnosis, epidemiology Humans Hydrogen-Ion Concentration Incidence Male Manometry Middle Aged Posture Prevalence |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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