Document Detail


Esophageal body and lower esophageal sphincter function in healthy premature infants.
MedLine Citation:
PMID:  7498639     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND & AIMS: Gastroesophageal reflux is a common problem in premature infants. The aim of this study was to use a novel manometric technique to measure esophageal body and lower esophageal sphincter pressures in premature infants. METHODS: Micromanometric feeding assemblies (OD, < or = 2 mm) incorporating 4-9 manometric channels were used in 49 studies of 27 premature neonates. Esophageal body motility was recorded at three sites for 20 minutes after feeding. Twenty attempts (one per minute) were made to stimulate swallowing via facial stimulation (Santmyer reflex). In 32 studies lower esophageal sphincter pressures were recorded (sleeve) for 15 minutes before and after feeding. RESULTS: Peristaltic motor patterns were less common than non-peristaltic motor patterns (26.6% vs. 73.4%; P < 0.0001) that comprised 31.1% synchronous, 34.6% incomplete, and 6.3% retrograde pressure waves. Reflex swallowing was elicited more frequently in neonates older than 34 weeks postconceptional age than in younger infants (33.4% vs. 20.4%; P < 0.05). Mean lower esophageal sphincter pressure was 20.5 +/- 1.7 mm Hg before and 13.7 +/- 1.3 mm Hg after feeding (P < 0.0005). CONCLUSIONS: Premature infants show nonperistaltic esophageal motility that may contribute to poor clearance of refluxed material. In contrast, the lower esophageal sphincter mechanisms seem well developed.
Authors:
T I Omari; K Miki; R Fraser; G Davidson; R Haslam; W Goldsworthy; M Bakewell; H Kawahara; J Dent
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Gastroenterology     Volume:  109     ISSN:  0016-5085     ISO Abbreviation:  Gastroenterology     Publication Date:  1995 Dec 
Date Detail:
Created Date:  1996-01-18     Completed Date:  1996-01-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0374630     Medline TA:  Gastroenterology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1757-64     Citation Subset:  AIM; IM    
Affiliation:
Department of Gastroenterology, Women's and Children's Hospital, North Adelaide, Australia.
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MeSH Terms
Descriptor/Qualifier:
Deglutition
Esophagogastric Junction / physiology*
Esophagus / physiology*
Female
Gastrointestinal Motility
Humans
Infant, Newborn
Infant, Premature / physiology*
Male
Manometry
Peristalsis
Physical Stimulation
Pressure
Reflex
Regression Analysis

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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