Document Detail

Esophageal Eosinophilia in Pediatric Patients with Celiac Disease; Is it a Causal or an Incidental Association?
MedLine Citation:
PMID:  25438025     Owner:  NLM     Status:  Publisher    
OBJECTIVES:: Celiac disease (CD) and eosinophilic esophagitis (EoE) are two distinct disease entities affecting the gastrointestinal tract of pediatric patients. Recently it has been suggested that eosinophilic esophagitis is more prevalent in patients with celiac disease than the general population. We studied the association between these two disease entities in our pediatric patients.
METHODS:: We reviewed our hospital files for suspected or confirmed cases of CD. Only cases with both duodenal and esophageal biopsies in pediatric patients were included. 120 patients who met these criteria were included as the disease group. We also selected 100 patients with no clinical suspicion of CD and included them as a control group. Slides were reviewed using established criteria for diagnosis of both conditions. Duodenal biopsies were categorized as positive, negative and suspicious for CD; whereas esophageal biopsies were classified as either positive or negative for esophageal eosinophilia. Serologic and clinical data were additionally collected.
RESULTS:: Sixty two (62) cases were considered positive for CD in the disease group; among those 4 (6.5%) showed esophageal eosinophilia. In the control group, 91 cases were negative for CD, histologically, and 7 of those had esophageal eosinophilia (7.7%). Although 6 patients in the control group were histologically suspicious for CD, none of them had evidence of esophageal eosinophilia.
CONCLUSION:: Our findings show that, in our patient population, CD patients are not more likely to have esophageal eosinophilia than patients undergoing upper endoscopy for other reasons. Therefore, we suggest that the association between CD and esophageal eosinophilia is likely incidental and not causal.
Omar I Ahmed; Shadi A Qasem; Jehan A Abdulsattar; Anthony N Snow; Ivor D Hill
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-11-25
Journal Detail:
Title:  Journal of pediatric gastroenterology and nutrition     Volume:  -     ISSN:  1536-4801     ISO Abbreviation:  J. Pediatr. Gastroenterol. Nutr.     Publication Date:  2014 Nov 
Date Detail:
Created Date:  2014-12-1     Completed Date:  -     Revised Date:  2014-12-2    
Medline Journal Info:
Nlm Unique ID:  8211545     Medline TA:  J Pediatr Gastroenterol Nutr     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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