| Esomeprazole: potent acid suppression in the treatment of acid-related disorders. | |
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MedLine Citation:
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PMID: 20477595 Owner: NLM Status: PubMed-not-MEDLINE |
Abstract/OtherAbstract:
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Esomeprazole (S-omeprazole), an enantiomer of the racemate omeprazole, is the first proton pump inhibitor to be developed as an isomer. This confers improved pharmacokinetics and pharmacodynamics compared with the racemate R/S-omeprazole. The difference in the pharmacokinetics of esomeprazole compared with omeprazole and the R-isomer is due to reductions in total body clearance and first-pass metabolism in the liver. Pharmacodynamic studies showed that esomeprazole 40 mg provides greater intragastric acid control than respective doses of all the other proton pump inhibitors on the market. Several well-designed clinical trials, employing both endoscopic and symptomatic response criteria, have compared the efficacy of esomeprazole with that of other proton pump inhibitors in the management of gastroesophageal reflux disease patients, and in the eradication of Helicobacter pylori. In addition, the efficacy of esomeprazole for the healing and prevention of nonsteroidal anti-inflammatory drug-associated dyspeptic symptoms and ulcers has been established. The aim of this review is to provide an overview of the pharmacokinetics, pharmacodynamics and consequent clinical importance of esomeprazole in the treatment of acid-related disorders. |
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Authors:
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A Morgner-Miehlke; Ku Petersen; S Miehlke; J Labenz |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Expert review of clinical immunology Volume: 1 ISSN: 1744-8409 ISO Abbreviation: Expert Rev Clin Immunol Publication Date: 2005 Nov |
Date Detail:
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Created Date: 2010-05-18 Completed Date: 2010-06-09 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101271248 Medline TA: Expert Rev Clin Immunol Country: England |
Other Details:
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Languages: eng Pagination: 511-27 Citation Subset: - |
Affiliation:
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Medical Department I, Gastroenterology, University Hospital, Fetscherstrasse 74, 01307 Dresden, Germany. Anrea.Morgner-Miehlke2@uniklinikum-dresden.de |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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