Document Detail

Eskimos have CHD despite high consumption of omega-3 fatty acids: the Alaska Siberia project.
MedLine Citation:
PMID:  16277122     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: The thirty-year-old hypothesis that omega-3 fatty acid (FA) may "reduce the development of thrombosis and atherosclerosis in the Western World" still needs to be tested. Dyerberg-Bang based their supposition on casual observations that coronary atherosclerosis in Greenlandic Inuit was 'almost unknown' and that they consumed large amounts of omega-3 FAs. However, no association was demonstrated with data. STUDY DESIGN: Cross-sectional study. METHODS: 454 Alaskan Eskimos were screened for coronary heart disease (CHD), using a protocol that included ECG, medical history, Rose questionnaire, blood chemistries, including plasma FA concentrations, and a 24-hour recall and a food frequency questionnaire assessment of omega-3 FA consumption. RESULTS: CHD was found in 6% of the cohort under 55 years of age and in 26% of those > or = 55 years of age. Eskimos with CHD consume as much omega-3 FAs as those without CHD, and the plasma concentrations confirm that dietary assessment. CONCLUSIONS: Average daily consumption of omega-3 FAs among Eskimos was high, with about 3-4 g/d reported, compared with 1-2 g/d used in intervention studies and the average consumption of 0.2 g/d by the American population. There was no association between current omega-3 FA consumption/blood concentrations and the presence of CHD.
Sven O E Ebbesson; Patricia M Risica; Lars O E Ebbesson; John M Kennish
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  International journal of circumpolar health     Volume:  64     ISSN:  1239-9736     ISO Abbreviation:  Int J Circumpolar Health     Publication Date:  2005 Sep 
Date Detail:
Created Date:  2005-11-09     Completed Date:  2005-12-12     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9713056     Medline TA:  Int J Circumpolar Health     Country:  Finland    
Other Details:
Languages:  eng     Pagination:  387-95     Citation Subset:  IM    
Department of Neurological Surgery, University of Virginia, Charlottesville 22908-0212, USA.
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MeSH Terms
Age Distribution
Alaska / epidemiology
Coronary Disease / blood*,  ethnology*
Cross-Sectional Studies
Diet / statistics & numerical data*
Fatty Acids, Omega-3 / blood*
Inuits / statistics & numerical data*
Middle Aged
Nutrition Surveys
Risk Factors
Grant Support
R01-47099//PHS HHS
Reg. No./Substance:
0/Fatty Acids, Omega-3

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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