| Escitalopram for severe asthma and major depressive disorder: a randomized, double-blind, placebo-controlled proof-of-concept study. | |
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MedLine Citation:
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PMID: 22221724 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Depression is common in asthma and may be a risk factor for asthma-related morbidity and mortality. However, minimal data are available on depression treatment in asthma. Previously, we reported greater sustained depression remission and less oral corticosteroid use in asthma patients treated with citalopram. METHOD: A 12-week randomized, double-blind, placebo-controlled, proof-of-concept trial of escitalopram was conducted in 26 outpatients with asthma requiring at least one course of oral corticosteroids in the prior 12 months and major depressive disorder (MDD) with baseline Hamilton Rating Scale for Depression (HAM-D) scores of ≥ 20. RESULTS: Total evaluable sample (n = 25) showed significant baseline to exit reduction in HAM-D and Inventory of Depressive Symptomatology-Self Report (IDS-SR) scores, with no significant between-group differences, although the findings favored escitalopram. Depression remission on the HAM-D, from week 1 to exit, showed a trend (P = 0.06) favoring escitalopram. Relative risk for remission at week 12 was 6.5 with an estimated remission rate of 39.1% with escitalopram and 6.0% with placebo. Between-group differences in oral corticosteroid use were not significant. Changes in Asthma Control Questionnaire (ACQ) correlated significantly with changes in IDS-SR in the escitalopram, placebo, and combined sample groups (τ = 0.49-0.60, P < 0.05) and with changes in HAM-D only in placebo and combined groups (τ = 0.38-0.58, P < 0.05). CONCLUSIONS: Medium effect sizes and a remission trend were observed favoring escitalopram over placebo on depression measures. Changes in self-reported depressive symptoms correlated with changes in asthma symptoms. A larger trial is needed to confirm the findings from this pilot study. |
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Authors:
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E Sherwood Brown; Christina Howard; David A Khan; Thomas J Carmody |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Psychosomatics Volume: 53 ISSN: 1545-7206 ISO Abbreviation: Psychosomatics Publication Date: 2012 Jan-Feb |
Date Detail:
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Created Date: 2012-01-06 Completed Date: 2012-04-11 Revised Date: 2012-04-24 |
Medline Journal Info:
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Nlm Unique ID: 0376506 Medline TA: Psychosomatics Country: England |
Other Details:
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Languages: eng Pagination: 75-80 Citation Subset: IM |
Copyright Information:
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Copyright © 2012 The Academy of Psychosomatic Medicine. Published by Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, TX 75390-8849, USA. Sherwood.Brown@UTSouthwestern.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adrenal Cortex Hormones / therapeutic use* Adult Aged Antidepressive Agents, Second-Generation / adverse effects, therapeutic use* Asthma / complications, drug therapy*, physiopathology Citalopram / adverse effects, therapeutic use* Depressive Disorder, Major / complications, drug therapy* Double-Blind Method Female Hospitalization Humans Male Middle Aged Pilot Projects Placebos Psychiatric Status Rating Scales Regression Analysis Remission Induction Self Report Spirometry Time Factors Treatment Outcome Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Adrenal Cortex Hormones; 0/Antidepressive Agents, Second-Generation; 0/Placebos; 59729-33-8/Citalopram |
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