Document Detail


Escin, a natural mixture of triterpene saponins, exhibits antitumor activity against hepatocellular carcinoma.
MedLine Citation:
PMID:  19579181     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Escin, a mixture of triterpene saponins extracted from Aesculus wilsonii Rehd., was used to analyze the antitumor effect in hepatocellular carcinoma in vivo and in vitro. At a dose of 2.8 mg/kg, escin had a rather high inhibition ratio (43.5 %) on mice H22 tumor growth in vivo. The results of the SRB cell viability assay showed that escin could induce significant concentration- and time-dependent inhibition of HepG (2) cell viability. Disruption of the G (1)/S phase of cell cycle progression accompanied by the induction of apoptosis were also observed in HepG (2) cells following escin treatment. The results of pulse-field gel electrophoresis and Western blot analysis show the induction of caspase-independent apoptosis by escin. This study provides evidence that escin induces cell cycle checkpoint arrest and caspase-independent cell death in HepG (2) cells, in support of its efficacious potential as a chemopreventive agent.
Authors:
Xue-ying Zhou; Feng-hua Fu; Zhen Li; Qiu-ju Dong; Jie He; Chang-hai Wang
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Planta medica     Volume:  75     ISSN:  1439-0221     ISO Abbreviation:  Planta Med.     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2009-12-17     Completed Date:  2010-04-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0066751     Medline TA:  Planta Med     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  1580-5     Citation Subset:  IM    
Copyright Information:
Georg Thieme Verlag KG Stuttgart. New York.
Affiliation:
School of Environmental & Biological Science & Technology, Dalian University of Technology, Dalian 116024, PR China.
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MeSH Terms
Descriptor/Qualifier:
Aesculus / chemistry*
Animals
Antineoplastic Agents, Phytogenic / pharmacology,  therapeutic use*
Apoptosis / drug effects
Carcinoma, Hepatocellular / drug therapy*
Cell Cycle / drug effects
Cell Line, Tumor
Cell Survival / drug effects*
Dose-Response Relationship, Drug
Escin / pharmacology,  therapeutic use*
Female
Hep G2 Cells
Humans
Liver Neoplasms / drug therapy*
Mice
Mice, Inbred Strains
Phytotherapy
Plant Extracts / pharmacology,  therapeutic use*
Xenograft Model Antitumor Assays
Chemical
Reg. No./Substance:
0/Antineoplastic Agents, Phytogenic; 0/Plant Extracts; 6805-41-0/Escin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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