| Escherichia coli outer membrane protein TolC is involved in production of the peptide antibiotic microcin J25. | |
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MedLine Citation:
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PMID: 10074099 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A Tn5 insertion in tolC eliminated microcin J25 production. The mutation had little effect on the expression of the microcin structural gene and presumably acted by blocking microcin secretion. The tolC mutants carrying multiple copies of the microcin genes were less immune to the microcin. TolC is thus likely a component of a microcin export complex containing the McjD immunity protein, an ABC exporter. |
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Authors:
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M A Delgado; J O Solbiati; M J Chiuchiolo; R N Farías; R A Salomón |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of bacteriology Volume: 181 ISSN: 0021-9193 ISO Abbreviation: J. Bacteriol. Publication Date: 1999 Mar |
Date Detail:
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Created Date: 1999-04-07 Completed Date: 1999-04-07 Revised Date: 2013-04-17 |
Medline Journal Info:
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Nlm Unique ID: 2985120R Medline TA: J Bacteriol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1968-70 Citation Subset: IM |
Affiliation:
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Departamento de Bioquímica de la Nutrición, INSIBIO Chacabuco 461, 4000 San Miguel de Tucumán, Argentina. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anti-Bacterial Agents
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biosynthesis* Bacterial Outer Membrane Proteins / genetics*, metabolism* Bacteriocins / biosynthesis*, genetics* Escherichia coli / genetics*, growth & development, metabolism* Escherichia coli Proteins Gene Expression Genes, Bacterial Membrane Transport Proteins Mutagenesis, Insertional Peptides* Phenotype Plasmids / genetics Porins / genetics |
| Chemical | |
Reg. No./Substance:
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0/Anti-Bacterial Agents; 0/Bacterial Outer Membrane Proteins; 0/Bacteriocins; 0/Escherichia coli Proteins; 0/Membrane Transport Proteins; 0/Peptides; 0/Porins; 0/tolC protein, E coli; 1403-96-9/microcin |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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