Document Detail

Escape from repeat-induced point mutation of a gene-sized duplication in Neurospora crassa crosses that are heterozygous for a larger chromosome segment duplication.
MedLine Citation:
PMID:  11290714     Owner:  NLM     Status:  MEDLINE    
In Neurospora crassa the ability of an ectopic gene-sized duplication to induce repeat-induced point mutation (RIP) in its target gene was suppressed in crosses that were heterozygous for another larger chromosome segment duplication. Specifically, the frequency of RIP in the erg-3 gene due to a 1.3-kb duplication was reduced if the chromosome segment duplications Dp(IIIR > [I;II]) AR17, Dp(VIR > IIIR) OY329, or Dp(IVR > VII) S1229 were present in either the same or the other parental nucleus of the premeiotic dikaryon. We suggest that the larger duplications act as sinks to titrate the RIP machinery away from the smaller duplication. In contrast, RIP efficiency was relatively unaffected in comparably unproductive interspecies crosses with N. intermedia and N. tetrasperma. These findings offer a novel explanation for the observed persistence of the transposable element Tad in only a subset of Neurospora strains.
A Bhat; D P Kasbekar
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Genetics     Volume:  157     ISSN:  0016-6731     ISO Abbreviation:  Genetics     Publication Date:  2001 Apr 
Date Detail:
Created Date:  2001-04-06     Completed Date:  2001-07-12     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0374636     Medline TA:  Genetics     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1581-90     Citation Subset:  IM    
Centre for Cellular and Molecular Biology, Hyderabad 500 007, India.
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MeSH Terms
Chromosomes, Fungal*
Crosses, Genetic
Crossing Over, Genetic*
Gene Duplication*
Genes, Fungal*
Neurospora crassa / genetics
Oxidoreductases / genetics*
Point Mutation*
Reg. No./Substance:
EC 1.-/Oxidoreductases; EC reductase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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