Document Detail

Erythropoietin treatment in peritoneal dialysis patients.
MedLine Citation:
PMID:  7948280     Owner:  NLM     Status:  MEDLINE    
The availability of recombinant EPO has greatly improved the lives of patients with end-stage renal disease. Knowledge is still accumulating regarding the use and effects of EPO in patients on PD, and several critical questions remain to be answered: 1. At what hematocrit level and when in the predialysis or dialysis course should EPO be started in PD patients? Recent studies by Golper suggest that the concomitant initiation of EPO and PD results in an increased hematocrit response compared to starting EPO after PD has been initiated for some time (63). 2. What is the best route of administration of EPO in PD patients? It is apparent that i.v., SC, and IP EPO can be effective in this population if utilized properly. The goal should be to tailor the route to the needs of the patient. Perhaps the daily SC route, for example, might be best for minimizing hypertension because of the slow, steady rise of hematocrit, while the IP route would be best tolerated by children (33,64). 3. What should the target hematocrit level be? This may vary depending on which organ function is being assessed. For the whole patient data are not currently available on appropriate hematocrit targets to maximize oxygen utilization, but near normal levels have recently been reported to be safe and beneficial (65-67). 4. What are the end-organ effects of anemia and its correction in PD patients? There is a dearth of information in this area for PD as well as HD patients. Additional research of this kind will increase our understanding of the pathophysiology of anemia as well as uremia.(ABSTRACT TRUNCATED AT 250 WORDS)
A R Nissenson
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis     Volume:  14 Suppl 3     ISSN:  0896-8608     ISO Abbreviation:  Perit Dial Int     Publication Date:  1994  
Date Detail:
Created Date:  1994-12-28     Completed Date:  1994-12-28     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8904033     Medline TA:  Perit Dial Int     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  S63-9     Citation Subset:  IM    
Division of Nephrology, UCLA School of Medicine 90024.
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MeSH Terms
Anemia / drug therapy*,  etiology
Clinical Trials as Topic
Erythropoietin / pharmacokinetics,  therapeutic use*
Kidney Failure, Chronic / complications*,  therapy
Peritoneal Dialysis*
Peritoneal Dialysis, Continuous Ambulatory*
Recombinant Proteins / pharmacokinetics,  therapeutic use
Reg. No./Substance:
0/Recombinant Proteins; 11096-26-7/Erythropoietin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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