Document Detail

Erythropoietin therapy and acute preoperative normovolaemic haemodilution in infants undergoing craniosynostosis surgery.
MedLine Citation:
PMID:  12791111     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: A retrospective study was performed to evaluate whether pretreatment with erythropoietin and iron combined with acute preoperative normovolaemic haemodilution (APNH) could decrease homologous blood transfusion in craniosynostosis (CS) surgery. A treated group was compared with a historical group of infants who underwent surgery with no pretreatment. METHODS: The charts of 25 healthy infants who underwent CS surgery were reviewed. Nine of them underwent surgery with no treatment beforehand. Sixteen infants were given erythropoietin at a dosage of 300 -1 two times per week and iron (elemental iron 10 for 3 weeks before surgery. On the day of surgery APNH was performed after induction of general anaesthesia; a precalculated amount of autologous blood was withdrawn and replaced by hydroxyethyl starch 6%. RESULTS: Eleven of the 16 infants of the study group received only autologous blood. Five of 16 received homologous blood transfusion vs seven of nine infants in the control group. CONCLUSIONS: APNH combined with erythropoietin was effective in reducing homologous blood requirements during CS surgery. Further studies are necessary on a larger scale to assess the role of this technique in avoiding homologous blood transfusion and to evaluate how infants can benefit from this combined approach.
Luisa Meneghini; Nicola Zadra; Vittorio Aneloni; Salvatore Metrangolo; Roberto Faggin; Franca Giusti
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Paediatric anaesthesia     Volume:  13     ISSN:  1155-5645     ISO Abbreviation:  Paediatr Anaesth     Publication Date:  2003 Jun 
Date Detail:
Created Date:  2003-06-06     Completed Date:  2003-10-15     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9206575     Medline TA:  Paediatr Anaesth     Country:  France    
Other Details:
Languages:  eng     Pagination:  392-6     Citation Subset:  IM    
Anesthesiology and Intensive Care Institute, Transfusion Medicine and Immune-Hematology and Pediatric Neurosurgery, University of Padua, Italy.
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MeSH Terms
Blood Transfusion
Craniosynostoses / surgery*
Erythropoietin, Recombinant / adverse effects,  therapeutic use*
Hetastarch / therapeutic use
Plasma Substitutes / therapeutic use
Preoperative Care
Retrospective Studies
Reg. No./Substance:
0/Erythropoietin, Recombinant; 0/Plasma Substitutes; 9005-27-0/Hetastarch

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