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Erythropoietin responsive cardiomyogenic cells contribute to heart repair post myocardial infarction.
MedLine Citation:
PMID:  24806289     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Introduction: The role of erythropoietin (Epo) in myocardial repair after infarction remains inconclusive. We observed high Epo receptor (EPOR) expression in cardiac progenitor cells (CPCs). Therefore, we aimed to characterize these cells and elucidate their contribution to myocardial regeneration upon Epo stimulation. Results: High EPOR expression was detected during murine embryonic heart development followed by a marked decrease until adulthood. EPOR positive cells in the adult heart were identified in a CPC-enriched cell population and showed co-expression of stem, mesenchymal, endothelial and cardiomyogenic cell markers. We focused on the population co-expressing early (TBX5, NKX2.5) and definitive (myosin heavy chain (MHC), cardiac Troponin T (cTNT)) cardiomyocyte markers. Epo increased their proliferation and thus were designated as Epo-responsive MHC expressing cells (EMCs). In vitro, EMCs proliferated and partially differentiated towards cardiomyocyte-like cells. Repetitive Epo administration in mice with myocardial infarction (cumulative dose 4 IU/g) resulted in an increase of cardiac EMCs and cTNT positive cells in the infarcted area. This was further accompanied by a significant preservation of cardiac function as compared to control mice. Conclusion: Our study characterized an EPO-responsive MHC-expressing cell population in the adult heart. Repetitive, moderate-dose Epo treatment enhanced the proliferation of EMCs resulting in preservation of post-ischemic cardiac function. Stem Cells 2014.
Authors:
Maria Patapia Zafiriou; Claudia Noack; Bernhard Unsöld; Michael Didie; Elena Pavlova; Henrike J Fischer; Holger M Reichardt; Martin W Bergmann; Ali El-Armouche; Wolfram Hubertus-Zimmermann; Laura Cecilia Zelarayan
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-5-8
Journal Detail:
Title:  Stem cells (Dayton, Ohio)     Volume:  -     ISSN:  1549-4918     ISO Abbreviation:  Stem Cells     Publication Date:  2014 May 
Date Detail:
Created Date:  2014-5-8     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9304532     Medline TA:  Stem Cells     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2014 AlphaMed Press.
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