Document Detail

Erythropoietin (rHuEPO) administration to premature infants for the treatment of their anemia.
MedLine Citation:
PMID:  9509504     Owner:  NLM     Status:  MEDLINE    
In an attempt to stimulate erythrocyte production and thereby decrease the requirement for red blood transfusions, recombinant human erythropoietin (rHuEPO) was administered to 16 premature infants with birth weights less than 1000 g and to 18 with birth weights of 1000-1300 g; two corresponding groups, who did not receive rHuEPO, were used as control groups. The rHuEPO was administered subcutaneously in a dose of 300 IU/kg three times a week for 6-8 weeks. The erythropoietin decreased the red blood requirement in both groups of infants, and the increment of hemoglobin following rHuEPO administration was not statistically significant. No correlation was observed between gestational age, number of transfusions, and reticulocyte percentage. The effect of rHuEPO was higher in the group of infants with birth weights of 1000-1300 g than in those of less than 1000 g. No significant side effects were observed during rHuEPO administration.
C Giannakopoulou; I Bolonaki; E Stiakaki; H Dimitriou; H Galanaki; E Hatzidaki; M Kalmanti
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Pediatric hematology and oncology     Volume:  15     ISSN:  0888-0018     ISO Abbreviation:  Pediatr Hematol Oncol     Publication Date:    1998 Jan-Feb
Date Detail:
Created Date:  1998-04-14     Completed Date:  1998-04-14     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8700164     Medline TA:  Pediatr Hematol Oncol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  37-43     Citation Subset:  IM    
Department of Pediatric Hematology/Oncology, Neonatal Intensive Care, University Hospital of Heraklion, Crete, Greece.
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MeSH Terms
Anemia, Neonatal / blood,  therapy*
Birth Weight
Blood Transfusion
Erythropoietin / therapeutic use*
Folic Acid / therapeutic use
Gestational Age
Hemoglobins / analysis
Infant, Low Birth Weight
Infant, Newborn
Infant, Premature*
Iron / therapeutic use
Recombinant Proteins / therapeutic use
Reticulocyte Count
Vitamin E / therapeutic use
Reg. No./Substance:
0/Hemoglobins; 0/Recombinant Proteins; 11096-26-7/Erythropoietin; 1406-18-4/Vitamin E; 59-30-3/Folic Acid; 7439-89-6/Iron

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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