| Erythropoietin (rHuEPO) administration to premature infants for the treatment of their anemia. | |
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MedLine Citation:
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PMID: 9509504 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In an attempt to stimulate erythrocyte production and thereby decrease the requirement for red blood transfusions, recombinant human erythropoietin (rHuEPO) was administered to 16 premature infants with birth weights less than 1000 g and to 18 with birth weights of 1000-1300 g; two corresponding groups, who did not receive rHuEPO, were used as control groups. The rHuEPO was administered subcutaneously in a dose of 300 IU/kg three times a week for 6-8 weeks. The erythropoietin decreased the red blood requirement in both groups of infants, and the increment of hemoglobin following rHuEPO administration was not statistically significant. No correlation was observed between gestational age, number of transfusions, and reticulocyte percentage. The effect of rHuEPO was higher in the group of infants with birth weights of 1000-1300 g than in those of less than 1000 g. No significant side effects were observed during rHuEPO administration. |
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Authors:
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C Giannakopoulou; I Bolonaki; E Stiakaki; H Dimitriou; H Galanaki; E Hatzidaki; M Kalmanti |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Pediatric hematology and oncology Volume: 15 ISSN: 0888-0018 ISO Abbreviation: Pediatr Hematol Oncol Publication Date: 1998 Jan-Feb |
Date Detail:
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Created Date: 1998-04-14 Completed Date: 1998-04-14 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8700164 Medline TA: Pediatr Hematol Oncol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 37-43 Citation Subset: IM |
Affiliation:
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Department of Pediatric Hematology/Oncology, Neonatal Intensive Care, University Hospital of Heraklion, Crete, Greece. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Anemia, Neonatal
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blood,
therapy* Birth Weight Blood Transfusion Erythropoietin / therapeutic use* Folic Acid / therapeutic use Gestational Age Hemoglobins / analysis Humans Infant, Low Birth Weight Infant, Newborn Infant, Premature* Iron / therapeutic use Recombinant Proteins / therapeutic use Reticulocyte Count Vitamin E / therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Hemoglobins; 0/Recombinant Proteins; 11096-26-7/Erythropoietin; 1406-18-4/Vitamin E; 59-30-3/Folic Acid; 7439-89-6/Iron |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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