Document Detail

Erythropoietin modulates the neural control of hypoxic ventilation.
MedLine Citation:
PMID:  19756385     Owner:  NLM     Status:  MEDLINE    
Numerous factors involved in general homeostasis are able to modulate ventilation. Classically, this comprises several kind of molecules, including neurotransmitters and steroids that are necessary for fine tuning ventilation under different conditions such as sleep, exercise, and acclimatization to high altitude. Recently, however, we have found that erythropoietin (Epo), the main regulator of red blood cell production, influences both central (brainstem) and peripheral (carotid bodies) respiratory centers when the organism is exposed to hypoxic conditions. Here, we summarize the effect of Epo on the respiratory control in mammals and highlight the potential implication of Epo in the ventilatory acclimatization to high altitude, as well as in the several respiratory sickness and syndromes occurring at low and high altitude.
Max Gassmann; Jorge Soliz
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Publication Detail:
Type:  Journal Article; Review     Date:  2009-09-10
Journal Detail:
Title:  Cellular and molecular life sciences : CMLS     Volume:  66     ISSN:  1420-9071     ISO Abbreviation:  Cell. Mol. Life Sci.     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2010-01-21     Completed Date:  2010-02-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9705402     Medline TA:  Cell Mol Life Sci     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  3575-82     Citation Subset:  IM    
Vetsuisse Faculty, Institute of Veterinary Physiology, Zurich Center for Integrative Human Physiology, University of Zurich, Winterthurerstrasse 260, 8057, Zurich, Switzerland.
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MeSH Terms
Adaptation, Physiological / drug effects,  physiology
Anoxia / physiopathology*
Carotid Body / drug effects,  physiopathology
Erythropoietin / blood,  pharmacology*,  physiology
Models, Biological
Nervous System Physiological Phenomena / drug effects*
Pulmonary Ventilation / drug effects*
Reg. No./Substance:

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