| Erythropoietin modulates the neural control of hypoxic ventilation. | |
| | |
MedLine Citation:
|
PMID: 19756385 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Numerous factors involved in general homeostasis are able to modulate ventilation. Classically, this comprises several kind of molecules, including neurotransmitters and steroids that are necessary for fine tuning ventilation under different conditions such as sleep, exercise, and acclimatization to high altitude. Recently, however, we have found that erythropoietin (Epo), the main regulator of red blood cell production, influences both central (brainstem) and peripheral (carotid bodies) respiratory centers when the organism is exposed to hypoxic conditions. Here, we summarize the effect of Epo on the respiratory control in mammals and highlight the potential implication of Epo in the ventilatory acclimatization to high altitude, as well as in the several respiratory sickness and syndromes occurring at low and high altitude. |
| | |
Authors:
|
Max Gassmann; Jorge Soliz |
Related Documents
:
|
19337745 - The effects of sildenafil and acetazolamide on breathing efficiency and ventilatory con... 2745305 - Operation everest ii: maximal oxygen uptake at extreme altitude. 21179255 - A pharmacy practice laboratory exercise to apply biochemistry concepts. 17181725 - Absence of population structure of turbot (psetta maxima) in the baltic sea. 7856805 - The influence of immobilization versus exercise on scar formation in the rabbit patella... 20040895 - Effects of various sodium bicarbonate loading protocols on the time-dependent extracell... |
Publication Detail:
|
Type: Journal Article; Review Date: 2009-09-10 |
Journal Detail:
|
Title: Cellular and molecular life sciences : CMLS Volume: 66 ISSN: 1420-9071 ISO Abbreviation: Cell. Mol. Life Sci. Publication Date: 2009 Nov |
Date Detail:
|
Created Date: 2010-01-21 Completed Date: 2010-02-01 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9705402 Medline TA: Cell Mol Life Sci Country: Switzerland |
Other Details:
|
Languages: eng Pagination: 3575-82 Citation Subset: IM |
Affiliation:
|
Vetsuisse Faculty, Institute of Veterinary Physiology, Zurich Center for Integrative Human Physiology, University of Zurich, Winterthurerstrasse 260, 8057, Zurich, Switzerland. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adaptation, Physiological
/
drug effects,
physiology Animals Anoxia / physiopathology* Carotid Body / drug effects, physiopathology Erythropoietin / blood, pharmacology*, physiology Humans Models, Biological Nervous System Physiological Phenomena / drug effects* Pulmonary Ventilation / drug effects* |
| Chemical | |
Reg. No./Substance:
|
11096-26-7/Erythropoietin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Breathing at high altitude.
Next Document: delta-Opioid receptors protect from anoxic disruption of Na+ homeostasis via Na+ channel regulation.