Document Detail


Erythropoietin increases reticulocyte counts and maintains hematocrit in neonates requiring surgery.
MedLine Citation:
PMID:  19635302     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Limited erythropoietin (Epo) production diminishes neonates' ability to regenerate blood removed by phlebotomy. Neonates requiring surgery are at risk to receive multiple transfusions. We sought to determine if recombinant Epo administration to neonates requiring surgery would stimulate erythropoiesis.
METHODS: Infants were randomized in double-masked fashion to receive Epo (200 units kg(-1) d(-1)) or placebo for 14 days. Complete blood count, absolute reticulocyte count (ARC), phlebotomy losses, and transfusions were measured during the study period. Infants were transfused using a strict transfusion protocol.
RESULTS: In the Epo group (n = 10, 2034 +/- 308 g, 8 +/- 2 days old; mean +/- SEM), ARC increased significantly, whereas in the placebo group (n = 10, 2400 +/- 184 g, 7 +/- 2 days old), ARC remained low. Hematocrits in the Epo group trended upward from 34.4 1.7% to 37.3 1.9% (although not statistically significant) despite phlebotomy losses of 53 +/- 12 mL/kg. Hematocrits in the placebo group were 35.9 1.8% and 33.2 1.6% on days 1 and 15, respectively, with phlebotomy losses of 27 +/- 5 mL/kg. There were no differences in absolute neutrophil counts or platelet counts between groups at the end of the study. No adverse effects were noted.
CONCLUSIONS: Infants randomized to Epo increased reticulocyte counts and hematocrits without adverse effects. Erythropoietin administration may provide an adjunct to present care in decreasing or eliminating erythrocyte transfusions in surgical neonates.
Authors:
Ryann Bierer; Mahshid Roohi; Connie Peceny; Robin K Ohls
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Journal of pediatric surgery     Volume:  44     ISSN:  1531-5037     ISO Abbreviation:  J. Pediatr. Surg.     Publication Date:  2009 Aug 
Date Detail:
Created Date:  2009-07-28     Completed Date:  2009-11-02     Revised Date:  2013-06-02    
Medline Journal Info:
Nlm Unique ID:  0052631     Medline TA:  J Pediatr Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1540-5     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, University of New Mexico, Albuquerque, NM 87131, USA.
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MeSH Terms
Descriptor/Qualifier:
Blood Component Transfusion
Double-Blind Method
Erythropoiesis / drug effects*
Erythropoietin / pharmacology*
Female
Hematocrit
Humans
Infant, Newborn
Male
Placebos
Preoperative Care*
Recombinant Proteins
Reticulocytes / drug effects*
Statistics, Nonparametric
Treatment Outcome
Grant Support
ID/Acronym/Agency:
HD00988/HD/NICHD NIH HHS; K11 HD000988/HD/NICHD NIH HHS; K11 HD000988-06/HD/NICHD NIH HHS; M01 RR 00997/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Placebos; 0/Recombinant Proteins; 11096-26-7/Erythropoietin
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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